Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line

K. K.W. Lam; R. T.K. Pang; C. L. Lee; H. Koistinen; M. Seppala; P. C. Ho; W. S.B. Yeung; P. C.N. Chiu

doi:10.1016/j.placenta.2012.06.001

Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line

K. K.W. Lam
, R. T.K. Pang
, C. L. Lee
, H. Koistinen
, M. Seppala
, P. C. Ho
, W. S.B. Yeung
, P. C.N. Chiu

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Cytotrophoblasts are the key trophoblast cells which differentiate into different trophoblast lineages. In this report, glycodelin-A action on fusion of a cytotrophoblast-like cell line (BeWo) was investigated. It significantly reduced the spontaneous fusion of BeWo cells. The treatment enhanced the invasion and extracellular-signal regulated kinases activation of BeWo cells. The mRNA expression of syncytialization markers, human chorionic gonadotrophin and glial cells missing homolog 1 were suppressed upon glycodelin-A treatment. The data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation. Crown

Original language	English
Pages (from-to)	750-752
Number of pages	3
Journal	Placenta
Volume	33
Issue number	9
DOIs	https://doi.org/10.1016/j.placenta.2012.06.001
Publication status	Published - Sept 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Differentiation
Fusion
Glycodelin
Human trophoblast
Invasion

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10.1016/j.placenta.2012.06.001

Cite this

@article{48241fa8bc3f41c38946cbd2e6e265ce,

title = "Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line",

abstract = "Cytotrophoblasts are the key trophoblast cells which differentiate into different trophoblast lineages. In this report, glycodelin-A action on fusion of a cytotrophoblast-like cell line (BeWo) was investigated. It significantly reduced the spontaneous fusion of BeWo cells. The treatment enhanced the invasion and extracellular-signal regulated kinases activation of BeWo cells. The mRNA expression of syncytialization markers, human chorionic gonadotrophin and glial cells missing homolog 1 were suppressed upon glycodelin-A treatment. The data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation. Crown",

keywords = "Differentiation, Fusion, Glycodelin, Human trophoblast, Invasion",

author = "Lam, \{K. K.W.\} and Pang, \{R. T.K.\} and Lee, \{C. L.\} and H. Koistinen and M. Seppala and Ho, \{P. C.\} and Yeung, \{W. S.B.\} and Chiu, \{P. C.N.\}",

note = "Funding Information: This work is supported in part by the Research Grant Council of Hong Kong (grants HKU7635/08M and HKU7803/08M ), Helsinki University Central Hospital Research Fund and the Academy of Finland .",

year = "2012",

month = sep,

doi = "10.1016/j.placenta.2012.06.001",

language = "English",

volume = "33",

pages = "750--752",

number = "9",

}

TY - JOUR

T1 - Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line

AU - Lam, K. K.W.

AU - Pang, R. T.K.

AU - Lee, C. L.

AU - Koistinen, H.

AU - Seppala, M.

AU - Ho, P. C.

AU - Yeung, W. S.B.

AU - Chiu, P. C.N.

N1 - Funding Information: This work is supported in part by the Research Grant Council of Hong Kong (grants HKU7635/08M and HKU7803/08M ), Helsinki University Central Hospital Research Fund and the Academy of Finland .

PY - 2012/9

Y1 - 2012/9

N2 - Cytotrophoblasts are the key trophoblast cells which differentiate into different trophoblast lineages. In this report, glycodelin-A action on fusion of a cytotrophoblast-like cell line (BeWo) was investigated. It significantly reduced the spontaneous fusion of BeWo cells. The treatment enhanced the invasion and extracellular-signal regulated kinases activation of BeWo cells. The mRNA expression of syncytialization markers, human chorionic gonadotrophin and glial cells missing homolog 1 were suppressed upon glycodelin-A treatment. The data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation. Crown

AB - Cytotrophoblasts are the key trophoblast cells which differentiate into different trophoblast lineages. In this report, glycodelin-A action on fusion of a cytotrophoblast-like cell line (BeWo) was investigated. It significantly reduced the spontaneous fusion of BeWo cells. The treatment enhanced the invasion and extracellular-signal regulated kinases activation of BeWo cells. The mRNA expression of syncytialization markers, human chorionic gonadotrophin and glial cells missing homolog 1 were suppressed upon glycodelin-A treatment. The data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation. Crown

KW - Differentiation

KW - Fusion

KW - Glycodelin

KW - Human trophoblast

KW - Invasion

UR - https://www.scopus.com/pages/publications/84865230615

U2 - 10.1016/j.placenta.2012.06.001

DO - 10.1016/j.placenta.2012.06.001

M3 - Article

C2 - 22748851

AN - SCOPUS:84865230615

SN - 0143-4004

VL - 33

SP - 750

EP - 752

JO - Placenta

JF - Placenta

IS - 9

ER -

Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line

Abstract

UN SDGs

Keywords

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