TY - JOUR
T1 - Unexpected Observations
T2 - Probiotic Administration Greatly Aggravates the Reproductive Toxicity of Perfluorobutanesulfonate in Zebrafish
AU - Tang, Lizhu
AU - Song, Shiwen
AU - Hu, Chenyan
AU - Lam, James C.W.
AU - Liu, Mengyuan
AU - Zhou, Bingsheng
AU - Lam, Paul K.S.
AU - Chen, Lianguo
N1 - Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/7/20
Y1 - 2020/7/20
N2 - The present study exposed adult zebrafish to 0, 10, and 100 μg/L perfluorobutanesulfonate (PFBS) with or without dietary supplement of probiotic Lactobacillus rhamnosus. Interaction between probiotic and PFBS on sex endocrine and reproduction was investigated. It was striking to find that PFBS and probiotic coexposures almost ceased the fecundity, which was accompanied by disturbances in sex hormones and oocyte maturation in females. In contrast, probiotic additive efficiently antagonized the estrogenic activity of PFBS in males. For the first time, this study reported that probiotic heavily depended on sex to modulate the endocrine disruption and reproductive toxicity of aquatic pollutants.
AB - The present study exposed adult zebrafish to 0, 10, and 100 μg/L perfluorobutanesulfonate (PFBS) with or without dietary supplement of probiotic Lactobacillus rhamnosus. Interaction between probiotic and PFBS on sex endocrine and reproduction was investigated. It was striking to find that PFBS and probiotic coexposures almost ceased the fecundity, which was accompanied by disturbances in sex hormones and oocyte maturation in females. In contrast, probiotic additive efficiently antagonized the estrogenic activity of PFBS in males. For the first time, this study reported that probiotic heavily depended on sex to modulate the endocrine disruption and reproductive toxicity of aquatic pollutants.
UR - http://www.scopus.com/inward/record.url?scp=85088496280&partnerID=8YFLogxK
U2 - 10.1021/acs.chemrestox.0c00139
DO - 10.1021/acs.chemrestox.0c00139
M3 - Article
C2 - 32372641
AN - SCOPUS:85088496280
SN - 0893-228X
VL - 33
SP - 1605
EP - 1608
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
IS - 7
ER -