TY - JOUR
T1 - TRPV2 calcium channel promotes breast cancer progression potential by activating autophagy
AU - Li, Qing
AU - Li, Huixian
AU - Zhu, Ruiwen
AU - Cho, William Chi Shing
AU - Yao, Xiaoqiang
AU - Leung, Fung Ping
AU - Tse, Gary
AU - Leung, Lai Kwok
AU - Wong, Wing Tak
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Breast cancer, the most prevalent and aggressive tumor affecting women, requires identification of disease determinants to facilitate the development of effective therapeutic strategies. Transient receptor potential vanilloid 2 (TRPV2), an ion channel highly permeable for calcium (Ca2+), is implicated in physiological and pathological processes. Nevertheless, the role of TRPV2 in breast cancer remains poorly elucidated. In this study, we found high levels of TRPV2 expression associated with advanced malignancy, thereby suggesting its potential as a biomarker for breast cancer staging. We demonstrated that TRPV2 activation promotes breast cancer cell proliferation, migration, and invasion, while silencing of TRPV2 suppresses breast cancer progression, highlighting the oncogenic role of TRPV2. Moreover, we reveal that TRPV2 facilitates cancer progression by modulating the CaMKKβ/AMPK/ULK1-autophagic axis through mediating calcium influx, providing new insights into TRPV2 as a novel therapeutic target for breast cancer treatment.
AB - Breast cancer, the most prevalent and aggressive tumor affecting women, requires identification of disease determinants to facilitate the development of effective therapeutic strategies. Transient receptor potential vanilloid 2 (TRPV2), an ion channel highly permeable for calcium (Ca2+), is implicated in physiological and pathological processes. Nevertheless, the role of TRPV2 in breast cancer remains poorly elucidated. In this study, we found high levels of TRPV2 expression associated with advanced malignancy, thereby suggesting its potential as a biomarker for breast cancer staging. We demonstrated that TRPV2 activation promotes breast cancer cell proliferation, migration, and invasion, while silencing of TRPV2 suppresses breast cancer progression, highlighting the oncogenic role of TRPV2. Moreover, we reveal that TRPV2 facilitates cancer progression by modulating the CaMKKβ/AMPK/ULK1-autophagic axis through mediating calcium influx, providing new insights into TRPV2 as a novel therapeutic target for breast cancer treatment.
KW - AMPK
KW - Autophagy
KW - Breast cancer
KW - CaMKKβ
KW - Calcium channel
KW - TRPV2
KW - ULK1
UR - http://www.scopus.com/inward/record.url?scp=85205461461&partnerID=8YFLogxK
U2 - 10.1186/s12935-024-03506-y
DO - 10.1186/s12935-024-03506-y
M3 - Article
AN - SCOPUS:85205461461
VL - 24
JO - Cancer Cell International
JF - Cancer Cell International
IS - 1
M1 - 324
ER -
