TY - GEN
T1 - Transcriptional cooperativity in molecular dynamics based on normal mode analysis
AU - Wang, Debby D.
AU - Yan, Hong
AU - He, Qiang
PY - 2012
Y1 - 2012
N2 - Transcriptional regulation is an important component in genetics, with transcriptional factors (TFs) and regulatory DNA regions involved in. In this paper, we observe cooperativity between two significant TFs Oct-l and Sox-2 at their enhancer DNA binding sites in collective motions. Normal mode analysis (NMA) is carried out to simulate the motions of two POU/HMG/DNA complexes, with molecular dynamics (MD) results used as a comparison. We have discovered several types of cooperative interactions between the two TFs in these obtained motions.
AB - Transcriptional regulation is an important component in genetics, with transcriptional factors (TFs) and regulatory DNA regions involved in. In this paper, we observe cooperativity between two significant TFs Oct-l and Sox-2 at their enhancer DNA binding sites in collective motions. Normal mode analysis (NMA) is carried out to simulate the motions of two POU/HMG/DNA complexes, with molecular dynamics (MD) results used as a comparison. We have discovered several types of cooperative interactions between the two TFs in these obtained motions.
KW - Embryonic Sstem Cells
KW - Normal Mode Analysis
KW - Protein Cooperativity
KW - Transcriptional Factors
UR - http://www.scopus.com/inward/record.url?scp=84871560078&partnerID=8YFLogxK
U2 - 10.1109/ICMLC.2012.6359491
DO - 10.1109/ICMLC.2012.6359491
M3 - Conference contribution
AN - SCOPUS:84871560078
SN - 9781467314855
T3 - Proceedings - International Conference on Machine Learning and Cybernetics
SP - 1001
EP - 1006
BT - Proceedings of 2012 International Conference on Machine Learning and Cybernetics, ICMLC 2012
T2 - 2012 International Conference on Machine Learning and Cybernetics, ICMLC 2012
Y2 - 15 July 2012 through 17 July 2012
ER -