The role of gap junctions in inflammatory and neoplastic disorders (Review)

Pui Wong, Victoria Laxton, Saurabh Srivastava, Yin Wah Fiona Chan, Gary Tse

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)

Abstract

Gap junctions are intercellular channels made of connexin proteins, mediating both electrical and biochemical signals between cells. The ability of gap junction proteins to regulate immune responses, cell proliferation, migration, apoptosis and carcinogenesis makes them attractive therapeutic targets for treating inflammatory and neoplastic disorders in different organ systems. Alterations in gap junction profile and expression levels are observed in hyperproliferative skin disorders, lymphatic vessel diseases, inflammatory lung diseases, liver injury and neoplastic disorders. It is now recognized that the therapeutic effects mediated by traditional pharmacological agents are dependent upon gap junction communication and may even act by influencing gap junction expression or function. Novel strategies for modulating the function or expression of connexins, such as the use of synthetic mimetic peptides and siRNA technology are considered.

Original languageEnglish
Pages (from-to)498-506
Number of pages9
JournalInternational Journal of Molecular Medicine
Volume39
Issue number3
DOIs
Publication statusPublished - Mar 2017
Externally publishedYes

Keywords

  • Cancer
  • Connexins
  • Gap junctions
  • Inflammation
  • Mimetic peptides

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