The immune functions of PCSK9: Local and systemic perspectives

Xing Liu, Rong Suo, Calista Zhuo Yi Chan, Tong Liu, Gary Tse, Guang Ping Li

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein receptor (LDLR) to trigger endocytosis and lysosome degradation in hepatocytes, regulating intracellular and plasma cholesterol levels. The discovery of PCSK9 has provided a new target for the management of hypercholesterolemia and cardiovascular risk reduction. There is emerging evidence that shows that PCSK9 may influence the activity of various cell types through either LDLR-dependent or LDLR-independent mechanisms. Changes in the circulating PCSK9 levels have been observed during infection and proinflammatory conditions. Furthermore, PCSK9 as a secreted protein has both local and systemic effects on cellular function. In this review, we summarize the roles of PCSK9 in inflammation.

Original languageEnglish
Pages (from-to)19180-19188
Number of pages9
JournalJournal of Cellular Physiology
Issue number11
Publication statusPublished - Nov 2019
Externally publishedYes


  • LDLR
  • PCSK9
  • cholesterol
  • inflammation
  • lipopolysaccharide


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