The immune functions of PCSK9: Local and systemic perspectives

Xing Liu; Rong Suo; Calista Zhuo Yi Chan; Tong Liu; Gary Tse; Guang Ping Li

doi:10.1002/jcp.28612

The immune functions of PCSK9: Local and systemic perspectives

Xing Liu, Rong Suo, Calista Zhuo Yi Chan, Tong Liu, Gary Tse, Guang Ping Li

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein receptor (LDLR) to trigger endocytosis and lysosome degradation in hepatocytes, regulating intracellular and plasma cholesterol levels. The discovery of PCSK9 has provided a new target for the management of hypercholesterolemia and cardiovascular risk reduction. There is emerging evidence that shows that PCSK9 may influence the activity of various cell types through either LDLR-dependent or LDLR-independent mechanisms. Changes in the circulating PCSK9 levels have been observed during infection and proinflammatory conditions. Furthermore, PCSK9 as a secreted protein has both local and systemic effects on cellular function. In this review, we summarize the roles of PCSK9 in inflammation.

Original language	English
Pages (from-to)	19180-19188
Number of pages	9
Journal	Journal of Cellular Physiology
Volume	234
Issue number	11
DOIs	https://doi.org/10.1002/jcp.28612
Publication status	Published - Nov 2019
Externally published	Yes

Keywords

LDLR
PCSK9
cholesterol
inflammation
lipopolysaccharide

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10.1002/jcp.28612

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title = "The immune functions of PCSK9: Local and systemic perspectives",

abstract = "Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein receptor (LDLR) to trigger endocytosis and lysosome degradation in hepatocytes, regulating intracellular and plasma cholesterol levels. The discovery of PCSK9 has provided a new target for the management of hypercholesterolemia and cardiovascular risk reduction. There is emerging evidence that shows that PCSK9 may influence the activity of various cell types through either LDLR-dependent or LDLR-independent mechanisms. Changes in the circulating PCSK9 levels have been observed during infection and proinflammatory conditions. Furthermore, PCSK9 as a secreted protein has both local and systemic effects on cellular function. In this review, we summarize the roles of PCSK9 in inflammation.",

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author = "Xing Liu and Rong Suo and Chan, {Calista Zhuo Yi} and Tong Liu and Gary Tse and Li, {Guang Ping}",

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T2 - Local and systemic perspectives

AU - Liu, Xing

AU - Suo, Rong

AU - Chan, Calista Zhuo Yi

AU - Liu, Tong

AU - Tse, Gary

AU - Li, Guang Ping

PY - 2019/11

Y1 - 2019/11

N2 - Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein receptor (LDLR) to trigger endocytosis and lysosome degradation in hepatocytes, regulating intracellular and plasma cholesterol levels. The discovery of PCSK9 has provided a new target for the management of hypercholesterolemia and cardiovascular risk reduction. There is emerging evidence that shows that PCSK9 may influence the activity of various cell types through either LDLR-dependent or LDLR-independent mechanisms. Changes in the circulating PCSK9 levels have been observed during infection and proinflammatory conditions. Furthermore, PCSK9 as a secreted protein has both local and systemic effects on cellular function. In this review, we summarize the roles of PCSK9 in inflammation.

AB - Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein receptor (LDLR) to trigger endocytosis and lysosome degradation in hepatocytes, regulating intracellular and plasma cholesterol levels. The discovery of PCSK9 has provided a new target for the management of hypercholesterolemia and cardiovascular risk reduction. There is emerging evidence that shows that PCSK9 may influence the activity of various cell types through either LDLR-dependent or LDLR-independent mechanisms. Changes in the circulating PCSK9 levels have been observed during infection and proinflammatory conditions. Furthermore, PCSK9 as a secreted protein has both local and systemic effects on cellular function. In this review, we summarize the roles of PCSK9 in inflammation.

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The immune functions of PCSK9: Local and systemic perspectives

Abstract

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