TY - JOUR
T1 - The Combination of Hyperuricemia and Elevated High-Sensitivity C-Reactive Protein Increased the Risk of Cardiac Conduction Block
AU - Li, Na
AU - Cui, Liufu
AU - Tse, Gary
AU - Korantzopoulos, Panagiotis
AU - Letsas, Konstantinos P.
AU - Bazoukis, George
AU - Chen, Shuohua
AU - Zhang, Nan
AU - Yang, Xuemei
AU - Liu, Peipei
AU - Wu, Lili
AU - Yan, Gan Xin
AU - Lip, Gregory Yoke Hong
AU - Wu, Shouling
AU - Liu, Tong
N1 - Publisher Copyright:
© 2024 Li et al.
PY - 2024
Y1 - 2024
N2 - Objective: This study aimed to explore the impact of a combination of hyperuricemia (HUA) and excessive high-sensitivity C-reactive protein (hs-CRP) levels on the likelihood of developing cardiac conduction block (CCB). Additionally, it sought to assess whether the influence of uric acid (UA) on CCB is mediated by hs-CRP. Methods: A prospective study was executed utilizing data from the Kailuan cohort, including 81,896 individuals initially free from CCB. The participants were categorized into four groups depending on the existence of HUA and low-grade inflammation (hs-CRP>3 mg/L). Cox regression analysis was employed to ascertain hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of incident CCB. A mediation analysis was performed to determine if hs-CRP functioned as a mediator in the connection between UA levels and the incidence of CCB. Results: During a median observation period of 11.8 years, we identified 3160 cases of newly occurring CCB. Compared with the low UA/low CRP group, the combination of HUA and low-grade inflammation elevated the CCB risks (HR:1.56, 95% CI:1.22–1.99), atrioventricular block (AVB) (HR:1.88, 95% CI:1.27–2.77), and right bundle branch block (HR:1.47, 95% CI:1.02–2.12), respectively. Mediation analysis revealed that in the HUA group, compared with the non-HUA group, the risk of CCB elevated by 14.0%, with 10.3% of the increase mediated through hs-CRP. Conclusion: HUA combined with elevated hs-CRP increased the risk of CCB, especially AVB. The connection between UA and the CCB risk was partly mediated by hs-CRP.
AB - Objective: This study aimed to explore the impact of a combination of hyperuricemia (HUA) and excessive high-sensitivity C-reactive protein (hs-CRP) levels on the likelihood of developing cardiac conduction block (CCB). Additionally, it sought to assess whether the influence of uric acid (UA) on CCB is mediated by hs-CRP. Methods: A prospective study was executed utilizing data from the Kailuan cohort, including 81,896 individuals initially free from CCB. The participants were categorized into four groups depending on the existence of HUA and low-grade inflammation (hs-CRP>3 mg/L). Cox regression analysis was employed to ascertain hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of incident CCB. A mediation analysis was performed to determine if hs-CRP functioned as a mediator in the connection between UA levels and the incidence of CCB. Results: During a median observation period of 11.8 years, we identified 3160 cases of newly occurring CCB. Compared with the low UA/low CRP group, the combination of HUA and low-grade inflammation elevated the CCB risks (HR:1.56, 95% CI:1.22–1.99), atrioventricular block (AVB) (HR:1.88, 95% CI:1.27–2.77), and right bundle branch block (HR:1.47, 95% CI:1.02–2.12), respectively. Mediation analysis revealed that in the HUA group, compared with the non-HUA group, the risk of CCB elevated by 14.0%, with 10.3% of the increase mediated through hs-CRP. Conclusion: HUA combined with elevated hs-CRP increased the risk of CCB, especially AVB. The connection between UA and the CCB risk was partly mediated by hs-CRP.
KW - cardiac conduction block
KW - combined exposure
KW - hyperuricemia
KW - inflammation
KW - mediation
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85196778475&partnerID=8YFLogxK
U2 - 10.2147/JIR.S458032
DO - 10.2147/JIR.S458032
M3 - Article
AN - SCOPUS:85196778475
VL - 17
SP - 3725
EP - 3736
JO - Journal of Inflammation Research
JF - Journal of Inflammation Research
ER -