TY - JOUR
T1 - Steroids prevent early recurrence of atrial fibrillation following catheter ablation
T2 - A systematic review and meta-analysis
AU - Lei, Ming
AU - Gong, Mengqi
AU - Bazoukis, George
AU - Letsas, Konstantinos P.
AU - Korantzopoulos, Panagiotis
AU - Li, Guangping
AU - Bisleri, Gianluigi
AU - Glover, Benedict
AU - Li, Ka Hou Christien
AU - Tse, Gary
AU - Baranchuk, Adrian
AU - Liu, Tong
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/10/17
Y1 - 2018/10/17
N2 - Previous studies have reported that steroids may reduce the risk of atrial fibrillation (AF) recurrence after catheter ablation, but data regarding this issue have been controversial. Therefore, we conducted a meta-analysis of randomized clinical trials (RCTs) and observational studies to ascertain the association of steroids and AF recurrence after ablation. PubMed, Embase, and Cochrane online databases were searched from inception to December 2017. The primary outcome of the meta-analysis was short-term or long-term AF recurrence following a single ablation procedure with or without the use of steroids. Both fixed- and random-effects models were used to calculate the overall effect estimates. Eight studies (four RCTs and four observational studies), with a total 992 patients, were included in the present study. Our meta-analysis shows that steroid use was associated with reduced AF occurrence at 3 months (odd ratio (OR) = 0.53, 95% confidence interval (CI) = 0.31–0.90, P=0.02) and 12–14 months (OR = 0.67, 95% CI = 0.47–0.95, P=0.02) after radiofrequency (RF) catheter ablation (RFCA). No clear benefit was observed for AF recurrence at 2–3 days, 1 or 24 months of follow-up. Steroid use was associated with decreased risk of early AF recurrence 3 and 12–14 months after ablation. No clear relationship was observed for 2–3 days, 1 and 24 months of follow-up and further data are needed to clarify these results.
AB - Previous studies have reported that steroids may reduce the risk of atrial fibrillation (AF) recurrence after catheter ablation, but data regarding this issue have been controversial. Therefore, we conducted a meta-analysis of randomized clinical trials (RCTs) and observational studies to ascertain the association of steroids and AF recurrence after ablation. PubMed, Embase, and Cochrane online databases were searched from inception to December 2017. The primary outcome of the meta-analysis was short-term or long-term AF recurrence following a single ablation procedure with or without the use of steroids. Both fixed- and random-effects models were used to calculate the overall effect estimates. Eight studies (four RCTs and four observational studies), with a total 992 patients, were included in the present study. Our meta-analysis shows that steroid use was associated with reduced AF occurrence at 3 months (odd ratio (OR) = 0.53, 95% confidence interval (CI) = 0.31–0.90, P=0.02) and 12–14 months (OR = 0.67, 95% CI = 0.47–0.95, P=0.02) after radiofrequency (RF) catheter ablation (RFCA). No clear benefit was observed for AF recurrence at 2–3 days, 1 or 24 months of follow-up. Steroid use was associated with decreased risk of early AF recurrence 3 and 12–14 months after ablation. No clear relationship was observed for 2–3 days, 1 and 24 months of follow-up and further data are needed to clarify these results.
UR - http://www.scopus.com/inward/record.url?scp=85055080194&partnerID=8YFLogxK
U2 - 10.1042/BSR20180462
DO - 10.1042/BSR20180462
M3 - Article
C2 - 30185438
AN - SCOPUS:85055080194
SN - 0144-8463
VL - 38
JO - Bioscience Reports
JF - Bioscience Reports
IS - 5
M1 - BSR20180462
ER -