Simple hematological predictors of AF recurrence in patients undergoing atrial fibrillation ablation

George Bazoukis, Konstantinos P. Letsas, Konstantinos Vlachos, Athanasios Saplaouras, Dimitrios Asvestas, Konstantinos Tyrovolas, Aikaterini Rokiza, Eirini Pagkalidou, Gary Tse, Stavros Stavrakis, Antonios Sideris, Michael Efremidis

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Backgound Red cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR) are simple hematologic indices that have been used to predict adverse outcomes in different clinical settings. The aim of our study is to determine whether RDW and NLR can predict atrial fibrillation (AF) recurrence in patients undergoing AF ablation. Methods Consecutive patients, without known hematological disorders, who underwent AF catheter ablation between January 2014 and April 2017 were enrolled into this study. Blood samples were taken one day before and five hours after the ablation procedure. Results A total of 346 patients (224 males (65%), mean age: 59 ± 11 years old) were included. After a mean follow up of 26.2 ± 12.1 months, 80 (23.1%) patients experienced late AF recurrence (defined as any recurrence after the blanking period of three months), while 97 (28%) patients experienced early AF recurrence during the blanking period. Univariate analysis showed that early arrhythmia recurrence, type of AF and NLR after the procedure were significantly associated with late AF recurrence, while early arrhythmia recurrence and NLR remained significant in multivariate analysis. RDW was not associated with late AF recurrence. None of the parameters above predicted early arrhythmia recurrence. Conclusions Simple and inexpensive hematological indices such as NLR should be evaluated for their ability to predict AF recurrence in patients undergoing catheter ablation in larger prospective studies.

Original languageEnglish
Pages (from-to)671-675
Number of pages5
JournalJournal of Geriatric Cardiology
Issue number9
Publication statusPublished - 2019
Externally publishedYes


  • Atrial fibrillation
  • Neutrophils
  • Radiofrequency ablation


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