Sample Optimization of Fast Authentication of Concentrated Chinese Medicine Granules Using FTIR-ATR with Chemometrics

S. H. Fung, E. S.W. Wong, C. Y. O, S. M.N. Chan, Tung Po Eric SZE, W. F. Tang, C. H. Li, F. W.F. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Concentrated Chinese medicine granules (CCMG) are the granular form of Chinese medicine that can be conveniently taken orally and have proven efficacy. In recent years, the quality of CCMG has raised public concern. Fourier transform infrared spectroscopy attenuated total reflection (FTIR-ATR) is a relatively simple, rapid and reliable analytical tool for Western drug verification, whereas application studies of FTIR-ATR for CCMG classification are very limited, possibly due to the higher chemical complexity in CCMG. To address this problem, FTIR-ATR coupled with chemometric and deep learning approaches are proposed. In this study, four species of CCMG, which share the same therapeutic function group, tonics, were selected for CCMG discrimination. The spectral data preprocessing, sample preparation method and spectral range selection for CCMG discrimination were optimized. This sample optimization analysis is essential for the subsequent deep learning analysis.

Original languageEnglish
Title of host publicationIntelligent Sustainable Systems - Selected Papers of WorldS4 2023
EditorsAtulya K. Nagar, Dharm Singh Jat, Durgesh Mishra, Amit Joshi
Pages465-474
Number of pages10
DOIs
Publication statusPublished - 2024
EventWorld Conference on Smart Trends in Systems, Security, and Sustainability, WS4 2023 - London, United Kingdom
Duration: 21 Aug 202324 Aug 2023

Publication series

NameLecture Notes in Networks and Systems
Volume803
ISSN (Print)2367-3370
ISSN (Electronic)2367-3389

Conference

ConferenceWorld Conference on Smart Trends in Systems, Security, and Sustainability, WS4 2023
Country/TerritoryUnited Kingdom
CityLondon
Period21/08/2324/08/23

Keywords

  • Authentication
  • CCMG
  • Chemometrics
  • Concentrated Chinese medicine granules
  • FTIR-ATR

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