Roles and mechanisms of fucoidan against dermatitis: A review

Fucoidan is a sulfate-containing polysaccharide derived from the cell walls of brown algae and marine invertebrates. Fucoidan is widely used for the treatment of various diseases owing to its various biological activities. Dermatitis is an inflammatory reaction that affects the skin. The primary clinical manifestations include atopic dermatitis (AD or eczema) and various subtypes of contact dermatitis. The treatment of dermatitis primarily improves symptoms and reduces inflammation. However, owing to individual variations, some patients have a poor prognosis or symptom recurrence after conventional treatment. Owing to the excellent anti-allergic and anti-inflammatory activities of the low cost nature compound fucoidan, its therapeutic effect in inflammatory diseases has recently attracted the attention of researchers. This article summarizes and analyzes the advantages and pharmacological mechanisms of fucoidan against dermatitis to provide a reference for the selection of drugs for the treatment of dermatitis.