TY - JOUR
T1 - Risk factors of dementia in type 2 diabetes mellitus
T2 - The Hong Kong diabetes study
AU - Chau, Yau Lam Alex
AU - Yoo, Ji Won
AU - Zhou, Jiandong
AU - LiutaoGuo, Cosmos
AU - Wong, Wing Tak
AU - Chang, Carlin
AU - Liu, Tong
AU - Jeevaratnam, Kamalan
AU - Zhang, Qingpeng
AU - Tse, Gary
AU - Lee, Sharen
N1 - Publisher Copyright:
© 2023
PY - 2023/9
Y1 - 2023/9
N2 - This population-based cohort study investigated the risk factors of incident dementia and vascular dementia in type 2 diabetic patients (≥45 years old) attending the Hong Kong Hospital Authority between 1st January and 31st December 2009.Of the 273,876 patients included,9994 showed incident dementia (median follow-up: 4245 days). Multivariable Cox regression identified older age (HR: 1.09 [95% CI: 1.08–1.10]) and antiplatelet use (HR: 1.36 [1.14–1.62]) as risk factors for incident dementia, and older age (HR: 1.07 [1.06–1.08]), ischemic stroke (HR: 1.47 [1.09–1.98]), fasting blood glucose (HR: 1.10 [1.01–1.20]), antiplatelets (HR: 1.92 [1.51–2.44]), and calcium channel blocker (HR: 1.28 [1.04–1.57]) use as risk factors of incident vascular dementia.
AB - This population-based cohort study investigated the risk factors of incident dementia and vascular dementia in type 2 diabetic patients (≥45 years old) attending the Hong Kong Hospital Authority between 1st January and 31st December 2009.Of the 273,876 patients included,9994 showed incident dementia (median follow-up: 4245 days). Multivariable Cox regression identified older age (HR: 1.09 [95% CI: 1.08–1.10]) and antiplatelet use (HR: 1.36 [1.14–1.62]) as risk factors for incident dementia, and older age (HR: 1.07 [1.06–1.08]), ischemic stroke (HR: 1.47 [1.09–1.98]), fasting blood glucose (HR: 1.10 [1.01–1.20]), antiplatelets (HR: 1.92 [1.51–2.44]), and calcium channel blocker (HR: 1.28 [1.04–1.57]) use as risk factors of incident vascular dementia.
KW - Dementia
KW - Risk factors
KW - Type 2 diabetes
KW - Vascular
UR - http://www.scopus.com/inward/record.url?scp=85174938045&partnerID=8YFLogxK
U2 - 10.1016/j.ahr.2023.100155
DO - 10.1016/j.ahr.2023.100155
M3 - Article
AN - SCOPUS:85174938045
VL - 3
JO - Aging and Health Research
JF - Aging and Health Research
IS - 3
M1 - 100155
ER -