Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics

Chanh Tin Pham; Xin Zhang; Austin Lam; Minh T.N. Le

doi:10.15698/cst2018.09.155

Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics

Chanh Tin Pham, Xin Zhang, Austin Lam, Minh T.N. Le

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

One of the major challenges of RNA-based therapeutics is the method for delivery of RNA molecules. In a recent article (Nat Commun 9(1):2359), we described a novel delivery platform for RNA-based drugs using red blood cell extracellular vesicles which can efficiently deliver both small and large RNAs to solid and liquid tumours. Our RBCEVs platform features exceptional merits over conventional RNA delivery methods in biosafety, biocompatibility, efficiency, accessibility, and cost effectiveness.

Original language	English
Pages (from-to)	239-241
Number of pages	3
Journal	Cell Stress
Volume	2
Issue number	9
DOIs	https://doi.org/10.15698/cst2018.09.155
Publication status	Published - Sept 2018
Externally published	Yes

Keywords

Cancer
Extracellular vesicles
Red blood cells
RNA
Therapeutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.15698/cst2018.09.155

Cite this

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title = "Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics",

abstract = "One of the major challenges of RNA-based therapeutics is the method for delivery of RNA molecules. In a recent article (Nat Commun 9(1):2359), we described a novel delivery platform for RNA-based drugs using red blood cell extracellular vesicles which can efficiently deliver both small and large RNAs to solid and liquid tumours. Our RBCEVs platform features exceptional merits over conventional RNA delivery methods in biosafety, biocompatibility, efficiency, accessibility, and cost effectiveness.",

keywords = "Cancer, Extracellular vesicles, Red blood cells, RNA, Therapeutics",

author = "Pham, {Chanh Tin} and Xin Zhang and Austin Lam and Le, {Minh T.N.}",

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year = "2018",

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AU - Pham, Chanh Tin

AU - Zhang, Xin

AU - Lam, Austin

AU - Le, Minh T.N.

PY - 2018/9

Y1 - 2018/9

N2 - One of the major challenges of RNA-based therapeutics is the method for delivery of RNA molecules. In a recent article (Nat Commun 9(1):2359), we described a novel delivery platform for RNA-based drugs using red blood cell extracellular vesicles which can efficiently deliver both small and large RNAs to solid and liquid tumours. Our RBCEVs platform features exceptional merits over conventional RNA delivery methods in biosafety, biocompatibility, efficiency, accessibility, and cost effectiveness.

AB - One of the major challenges of RNA-based therapeutics is the method for delivery of RNA molecules. In a recent article (Nat Commun 9(1):2359), we described a novel delivery platform for RNA-based drugs using red blood cell extracellular vesicles which can efficiently deliver both small and large RNAs to solid and liquid tumours. Our RBCEVs platform features exceptional merits over conventional RNA delivery methods in biosafety, biocompatibility, efficiency, accessibility, and cost effectiveness.

KW - Cancer

KW - Extracellular vesicles

KW - Red blood cells

KW - RNA

KW - Therapeutics

UR - http://www.scopus.com/inward/record.url?scp=85079237846&partnerID=8YFLogxK

U2 - 10.15698/cst2018.09.155

DO - 10.15698/cst2018.09.155

M3 - Review article

AN - SCOPUS:85079237846

VL - 2

SP - 239

EP - 241

JO - Cell Stress

JF - Cell Stress

IS - 9

ER -

Red blood cell extracellular vesicles as robust carriers of RNA-based therapeutics

Abstract

Keywords

UN SDGs

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