Recent developments in palladium-catalysed non-directed coupling of (hetero)arene C-H bonds with C-Z (Z = B, Si, Sn, S, N, C, H) bonds in bi(hetero)aryl synthesis

Transition metal-catalysed C-H bond functionalisation is an attractive approach for assembling valuable complex intermediates for the synthesis of pharmaceuticals, natural products, agrochemicals and fine chemicals. Selective functionalisation of one specific C-H site within a complex molecule without the assistance of a directing group is one of the major challenges in organic synthesis. The non-directed functionalisation of C-H bonds is more attractive and straightforward than the directed approach. While several reviews have covered (hetero)aryl (pseudo)halides as coupling partners in non-directed C-H bond functionalisation, this review will complement these existing contributions by focusing on the recent developments involving the employment of organometallic reagents for palladium-catalysed non-directed C-H bond functionalisation of (hetero)arene C-H bonds. Additionally, C-H/C-H bond coupling and other coupling partners will also be fully described.