Abstract
G-401A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children. We studied whether gain-of-function mutations in RANTES gene were associated with asthma and atopy-related traits in Chinese children. Plasma total and aeroallergen-specific IgE concentrations were measured using micro-particle immunoassay and fluorescent enzyme immunoassay, respectively. Restriction fragment length polymorphism was used to genotype RANTES G-401A and C-28G. One hundred and twenty-nine asthmatic children and 66 controls were recruited. Their mean logarithmic plasma total IgE concentrations were 2.53 and 1.98, respectively (P<0.0001). RANTES G-401A was not associated with physician-diagnosed asthma (P=0.408). However, RANTES -401A allele was significantly associated with IgE sensitization to cat (odds ratio 2.35; 95% CI 1.15-4.77; P=0.010). Those homozygous for -401A had higher plasma cat-specific IgE levels (P=0.034). Subjects having -401A were also more likely to have mold-specific IgE (odds ratio 3.82; 95% CI 1.24-12.14; P=0.007). On spirometry, those with -401A/A had lower forced expiratory volume in 1-s (FEV1; P=0.044). RANTES C-28G was not associated with any outcome in this study. In conclusion, the gain-of-function mutation at -401 of RANTES promoter is associated with sensitization to cat and mold allergens and FEV1 in Chinese children.
Original language | English |
---|---|
Pages (from-to) | 216-219 |
Number of pages | 4 |
Journal | Respiratory Medicine |
Volume | 99 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2005 |
Externally published | Yes |
Keywords
- Asthma
- Atopy
- Polymorphism
- Regulated on activation, normal T cell expressed and secreted
- Spirometry