RANTES G-401A polymorphism is associated with allergen sensitization and FEV1 in Chinese children

T. F. Leung, N. L.S. Tang, C. W.K. Lam, A. M. Li, S. L.M. Fung, I. H.S. Chan, G. W.K. Wong

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

G-401A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children. We studied whether gain-of-function mutations in RANTES gene were associated with asthma and atopy-related traits in Chinese children. Plasma total and aeroallergen-specific IgE concentrations were measured using micro-particle immunoassay and fluorescent enzyme immunoassay, respectively. Restriction fragment length polymorphism was used to genotype RANTES G-401A and C-28G. One hundred and twenty-nine asthmatic children and 66 controls were recruited. Their mean logarithmic plasma total IgE concentrations were 2.53 and 1.98, respectively (P<0.0001). RANTES G-401A was not associated with physician-diagnosed asthma (P=0.408). However, RANTES -401A allele was significantly associated with IgE sensitization to cat (odds ratio 2.35; 95% CI 1.15-4.77; P=0.010). Those homozygous for -401A had higher plasma cat-specific IgE levels (P=0.034). Subjects having -401A were also more likely to have mold-specific IgE (odds ratio 3.82; 95% CI 1.24-12.14; P=0.007). On spirometry, those with -401A/A had lower forced expiratory volume in 1-s (FEV1; P=0.044). RANTES C-28G was not associated with any outcome in this study. In conclusion, the gain-of-function mutation at -401 of RANTES promoter is associated with sensitization to cat and mold allergens and FEV1 in Chinese children.

Original languageEnglish
Pages (from-to)216-219
Number of pages4
JournalRespiratory Medicine
Volume99
Issue number2
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

Keywords

  • Asthma
  • Atopy
  • Polymorphism
  • Regulated on activation, normal T cell expressed and secreted
  • Spirometry

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