Abstract
The pathogenesis of chemotherapy-induced gastrointestinal mucositis is not fully elucidated, which makes it extremely difficult to develop effective interventions. Recently, the use of animal models of chemotherapy-induced gastrointestinal mucositis has led to advances in the understanding of cellular mechanisms and clinical pharmacology of various types of chemotherapy drugs. Tumor-bearing models, non-tumorbearing models, transgenic models and gene knockout models have been developed to assess the effect of chemotherapy on chemotherapyinduced gastrointestinal mucositis. In this paper, we comprehensively analyze the advantages and disadvantages of various methods for developing chemotherapy-induced gastrointestinal mucositis to provide a reference for the choice of animal models for future research of chemotherapy- associated mucosal toxicity and the underlying mechanisms.
Original language | English |
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Pages (from-to) | 649-655 |
Number of pages | 7 |
Journal | World Chinese Journal of Digestology |
Volume | 20 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2012 |
Externally published | Yes |
Keywords
- Animal model
- Chemically induced
- Gastrointestinal mucositis
- Intestinal mucosal barrier injury