Progress towards the development of animal models of chemotherapy-induced gastrointestinal mucositis

Min Zhang, Jin Xiu Chen, Jing Yu Tan, Xian Liang Liu

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The pathogenesis of chemotherapy-induced gastrointestinal mucositis is not fully elucidated, which makes it extremely difficult to develop effective interventions. Recently, the use of animal models of chemotherapy-induced gastrointestinal mucositis has led to advances in the understanding of cellular mechanisms and clinical pharmacology of various types of chemotherapy drugs. Tumor-bearing models, non-tumorbearing models, transgenic models and gene knockout models have been developed to assess the effect of chemotherapy on chemotherapyinduced gastrointestinal mucositis. In this paper, we comprehensively analyze the advantages and disadvantages of various methods for developing chemotherapy-induced gastrointestinal mucositis to provide a reference for the choice of animal models for future research of chemotherapy- associated mucosal toxicity and the underlying mechanisms.

Original languageEnglish
Pages (from-to)649-655
Number of pages7
JournalWorld Chinese Journal of Digestology
Volume20
Issue number8
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Animal model
  • Chemically induced
  • Gastrointestinal mucositis
  • Intestinal mucosal barrier injury

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