TY - JOUR
T1 - Prognosis, risk stratification, and management of asymptomatic individuals with Brugada syndrome
T2 - A systematic review
AU - Letsas, Konstantinos P.
AU - Asvestas, Dimitrios
AU - Baranchuk, Adrian
AU - Liu, Tong
AU - Georgopoulos, Stamatis
AU - Efremidis, Michael
AU - Korantzopoulos, Panagiotis
AU - Bazoukis, George
AU - Tse, Gary
AU - Sideris, Antonios
AU - Takagi, Masahiko
AU - Ehrlich, Joachim R.
N1 - Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2017/12
Y1 - 2017/12
N2 - Brugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification, and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter-defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow-up of patients living with such devices, and the accompanying impairment of the quality of life. Several clinical, electrocardiographic, and electrophysiological markers have been proposed for risk stratification of subjects with BrS phenotype, but the majority have not yet been tested in a prospective manner in asymptomatic individuals. Recent data suggest that current risk factors are insufficient and cannot accurately predict sudden cardiac death events in this setting. This systematic review aims to discuss contemporary data regarding prognosis, risk stratification, and management of asymptomatic individuals with diagnosis of Brugada electrocardiogram pattern and to delineate the therapeutic approach in such cases.
AB - Brugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification, and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter-defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow-up of patients living with such devices, and the accompanying impairment of the quality of life. Several clinical, electrocardiographic, and electrophysiological markers have been proposed for risk stratification of subjects with BrS phenotype, but the majority have not yet been tested in a prospective manner in asymptomatic individuals. Recent data suggest that current risk factors are insufficient and cannot accurately predict sudden cardiac death events in this setting. This systematic review aims to discuss contemporary data regarding prognosis, risk stratification, and management of asymptomatic individuals with diagnosis of Brugada electrocardiogram pattern and to delineate the therapeutic approach in such cases.
KW - Brugada syndrome
KW - risk stratification
KW - sudden cardiac death
UR - http://www.scopus.com/inward/record.url?scp=85034019683&partnerID=8YFLogxK
U2 - 10.1111/pace.13214
DO - 10.1111/pace.13214
M3 - Review article
C2 - 28994463
AN - SCOPUS:85034019683
SN - 0147-8389
VL - 40
SP - 1332
EP - 1345
JO - PACE - Pacing and Clinical Electrophysiology
JF - PACE - Pacing and Clinical Electrophysiology
IS - 12
ER -