Preparation of 2-(2-(dicyclohexylphosphino)phenyl)-1-methyl-1h-indole (CM-phos)

The article describes the preparation of 2-(2-(Dicyclohexylphosphino) phenyl)-1-methyl-1H-indole (CM-phos).We selected the Fischer indole synthesis as our primary tool to synthesize the indole templates from phenylhydrazine and 2’-bromoacetophenone. With the methylated ligand precursor, CM-phos could be afforded easily by lithiation and subsequently trapping with chlorodicyclohexylphosphine. It should be noted that CM-phos in combination with the precatalyst palladium(II) acetate is highly active and effective in amination and Suzuki cross-coupling reaction of aryl mesylates.