TY - JOUR
T1 - Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests
T2 - A Comprehensive Systematic Review with Meta-Analysis
AU - Weymann, Alexander
AU - Ali-Hasan-Al-Saegh, Sadeq
AU - Sabashnikov, Anton
AU - Popov, Aron Frederik
AU - Mirhosseini, Seyed Jalil
AU - Liu, Tong
AU - Lotfaliani, Mohammadreza
AU - Sá, Michel Pompeu Barros de Oliveira
AU - Baker, William L.L.
AU - Yavuz, Senol
AU - Zeriouh, Mohamed
AU - Jang, Jae Sik
AU - Dehghan, Hamidreza
AU - Meng, Lei
AU - Testa, Luca
AU - D'Ascenzo, Fabrizio
AU - Benedetto, Umberto
AU - Tse, Gary
AU - Nombela-Franco, Luis
AU - Dohmen, Pascal M.
AU - Deshmukh, Abhishek J.
AU - Linde, Cecilia
AU - Biondi-Zoccai, Giuseppe
AU - Stone, Gregg W.
AU - Calkins, Hugh
AU - Surgery, Integrated Meta Analysis Of Cardiac
PY - 2017/5/12
Y1 - 2017/5/12
N2 - BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS The literature search of all major databases retrieved 2150 studies. After screening, 70 studies were analyzed in the meta-analysis on new-onset AF and 23 studies on recurrent AF. Pooled analysis on new-onset AF showed platelet count (PC) (weighted mean difference (WMD)=WMD of -26.39×10^9/L and p<0.001), mean platelet volume (MPV) (WMD=0.42 FL and p<0.001), white blood cell (WBC) (WMD=-0.005×10^9/L and p=0.83), neutrophil to lymphocyte ratio (NLR) (WMD=0.89 and p<0.001), and red blood cell distribution width (RDW) (WMD=0.61% and p<0.001) as associated factors. Pooled analysis on recurrent AF revealed PC (WMD=-2.71×109/L and p=0.59), WBC (WMD=0.20×10^9/L (95% CI: 0.08 to 0.32; p=0.002), NLR (WMD=0.37 and p<0.001), and RDW (WMD=0.28% and p<0.001). CONCLUSIONS Hematological parameters have significant ability to predict occurrence and recurrence of AF. Therefore, emphasizing the potential predictive role of hematological parameters for new-onset and recurrent AF, we recommend adding the CBC test to the diagnostic modalities of AF in clinical practice.
AB - BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS The literature search of all major databases retrieved 2150 studies. After screening, 70 studies were analyzed in the meta-analysis on new-onset AF and 23 studies on recurrent AF. Pooled analysis on new-onset AF showed platelet count (PC) (weighted mean difference (WMD)=WMD of -26.39×10^9/L and p<0.001), mean platelet volume (MPV) (WMD=0.42 FL and p<0.001), white blood cell (WBC) (WMD=-0.005×10^9/L and p=0.83), neutrophil to lymphocyte ratio (NLR) (WMD=0.89 and p<0.001), and red blood cell distribution width (RDW) (WMD=0.61% and p<0.001) as associated factors. Pooled analysis on recurrent AF revealed PC (WMD=-2.71×109/L and p=0.59), WBC (WMD=0.20×10^9/L (95% CI: 0.08 to 0.32; p=0.002), NLR (WMD=0.37 and p<0.001), and RDW (WMD=0.28% and p<0.001). CONCLUSIONS Hematological parameters have significant ability to predict occurrence and recurrence of AF. Therefore, emphasizing the potential predictive role of hematological parameters for new-onset and recurrent AF, we recommend adding the CBC test to the diagnostic modalities of AF in clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=85041211069&partnerID=8YFLogxK
U2 - 10.12659/msmbr.903320
DO - 10.12659/msmbr.903320
M3 - Article
C2 - 28496093
AN - SCOPUS:85041211069
VL - 23
SP - 179
EP - 222
JO - Medical science monitor basic research
JF - Medical science monitor basic research
ER -
