Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen Xiu Ni; Wai Lun Man; Shek Man Yiu; Man Ho; Myra Ting Wai Cheung; Chi Chiu Ko; Chi Ming Che; Yun Wah Lam; Tai Chu Lau

doi:10.1039/c2sc01031c

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen Xiu Ni
, Wai Lun Man
, Shek Man Yiu
, Man Ho
, Myra Ting Wai Cheung
, Chi Chiu Ko
, Chi Ming Che
, Yun Wah Lam
, Tai Chu Lau

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Eight new nitridoosmium(vi) complexes with the general formula [Os ^VI(N)Cl ₃(Hazole) ₂] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

Original language	English
Pages (from-to)	1582-1588
Number of pages	7
Journal	Chemical Science
Volume	3
Issue number	5
DOIs	https://doi.org/10.1039/c2sc01031c
Publication status	Published - May 2012
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1039/c2sc01031c

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title = "Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents",

abstract = "Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.",

author = "Ni, \{Wen Xiu\} and Man, \{Wai Lun\} and Yiu, \{Shek Man\} and Man Ho and Cheung, \{Myra Ting Wai\} and Ko, \{Chi Chiu\} and Che, \{Chi Ming\} and Lam, \{Yun Wah\} and Lau, \{Tai Chu\}",

year = "2012",

month = may,

doi = "10.1039/c2sc01031c",

language = "English",

volume = "3",

pages = "1582--1588",

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}

TY - JOUR

T1 - Osmium(vi) nitrido complexes bearing azole heterocycles

T2 - A new class of antitumor agents

AU - Ni, Wen Xiu

AU - Man, Wai Lun

AU - Yiu, Shek Man

AU - Ho, Man

AU - Cheung, Myra Ting Wai

AU - Ko, Chi Chiu

AU - Che, Chi Ming

AU - Lam, Yun Wah

AU - Lau, Tai Chu

PY - 2012/5

Y1 - 2012/5

N2 - Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

AB - Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

UR - https://www.scopus.com/pages/publications/84859336852

U2 - 10.1039/c2sc01031c

DO - 10.1039/c2sc01031c

M3 - Article

AN - SCOPUS:84859336852

SN - 2041-6520

VL - 3

SP - 1582

EP - 1588

JO - Chemical Science

JF - Chemical Science

IS - 5

ER -

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Abstract

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