TY - JOUR
T1 - Mutual Information Reveals Non-linear Relationships between Electrocardiographic Conduction or Repolarization Indices and Mechanical Dispersion by Speckle-Tracking Echocardiography in the General Population
AU - Ciobanu, Ana
AU - Gheorghe, Gabriela Silvia
AU - Inţă, Oana Mihaela
AU - Zhou, Jiandong
AU - Zhang, Qingpeng
AU - Tse, Gary
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/5
Y1 - 2021/5
N2 - Electrical inhomogeneities can lead to regional heterogeneity in left ventricular contraction. We investigated the correlation between electrocardiographic parameters of conduction and/or repolarization and myocardial longitudinal strain-derived parameters in a general population. Mean and dispersion (maximum–minimum) values were calculated for the electrocardiographic indices: QT interval, Tpeak–Tend interval (Tpe), JTpeak interval (JTp), JTend interval (JTe), QTpeak interval (QTp). Mechanical dispersion was assessed using the standard deviation (SD) of time-to-peak longitudinal strains (MDSD) and the difference between the longest time and shortest time to peak strain (MDdelta) by speckle-tracking echocardiography. A total of 59 patients, 60 ± 12 y, were included. Tpe, Tpe/QT, Tpe/JTp and Tpe/JTe correlated well with MDSD and MDdelta (r ≥ 0.43, p < 0.001). Mutual information revealed significant non-linear relationships between most of the electrocardiographic indices measured and mechanical dispersion. In conclusion, there is a moderate linear correlation between electrocardiographic indices reflecting repolarization heterogeneities and speckle tracking-assessed mechanical dispersion.
AB - Electrical inhomogeneities can lead to regional heterogeneity in left ventricular contraction. We investigated the correlation between electrocardiographic parameters of conduction and/or repolarization and myocardial longitudinal strain-derived parameters in a general population. Mean and dispersion (maximum–minimum) values were calculated for the electrocardiographic indices: QT interval, Tpeak–Tend interval (Tpe), JTpeak interval (JTp), JTend interval (JTe), QTpeak interval (QTp). Mechanical dispersion was assessed using the standard deviation (SD) of time-to-peak longitudinal strains (MDSD) and the difference between the longest time and shortest time to peak strain (MDdelta) by speckle-tracking echocardiography. A total of 59 patients, 60 ± 12 y, were included. Tpe, Tpe/QT, Tpe/JTp and Tpe/JTe correlated well with MDSD and MDdelta (r ≥ 0.43, p < 0.001). Mutual information revealed significant non-linear relationships between most of the electrocardiographic indices measured and mechanical dispersion. In conclusion, there is a moderate linear correlation between electrocardiographic indices reflecting repolarization heterogeneities and speckle tracking-assessed mechanical dispersion.
KW - Index of electrophysiological balance
KW - Longitudinal strain;Mechanical dispersion
KW - Speckle-tracking echocardiography
KW - T–T interval
UR - http://www.scopus.com/inward/record.url?scp=85101379672&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2021.01.027
DO - 10.1016/j.ultrasmedbio.2021.01.027
M3 - Article
C2 - 33622621
AN - SCOPUS:85101379672
SN - 0301-5629
VL - 47
SP - 1408
EP - 1420
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 5
ER -