Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

Bing Huang; Zhanghua Chen; Lanlan Geng; Jun Wang; Huiying Liang; Yujie Cao; Huan Chen; Wanming Huang; Meiling Su; Hanqing Wang; Yanhui Xu; Yukun Liu; Bingtai Lu; Huifang Xian; Huiwen Li; Huilin Li; Lu Ren; Jing Xie; Liping Ye; Hongli Wang; Junhong Zhao; Peiyu Chen; Li Zhang; Shanmeizi Zhao; Ting Zhang; Banglao Xu; Di Che; Wenyue Si; Xiaoqiong Gu; Liang Zeng; Yong Wang; Dingyou Li; Yifan Zhan; David Delfouneso; Andrew M. Lew; Jun Cui; Wai Ho Tang; Yan Zhang; Sitang Gong; Fan Bai; Min Yang; Yuxia Zhang

doi:10.1016/j.cell.2019.10.027

Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

Bing Huang, Zhanghua Chen, Lanlan Geng, Jun Wang, Huiying Liang, Yujie Cao, Huan Chen, Wanming Huang, Meiling Su, Hanqing Wang, Yanhui Xu, Yukun Liu, Bingtai Lu, Huifang Xian, Huiwen Li, Huilin Li, Lu Ren, Jing Xie, Liping Ye, Hongli WangJunhong Zhao, Peiyu Chen, Li Zhang, Shanmeizi Zhao, Ting Zhang, Banglao Xu, Di Che, Wenyue Si, Xiaoqiong Gu, Liang Zeng, Yong Wang, Dingyou Li, Yifan Zhan, David Delfouneso, Andrew M. Lew, Jun Cui, Wai Ho Tang, Yan Zhang, Sitang Gong, Fan Bai, Min Yang, Yuxia Zhang

Research output: Contribution to journal › Article › peer-review

179 Citations (Scopus)

Abstract

Single-cell and risk gene analysis of children with undifferentiated colitis, Crohn's disease, and ulcerative colitis identifies common underlying mechanisms of pathogenesis and reveals the potential therapeutic benefit of modulating cAMP signaling via the drug dipyridamole.

Original language	English
Pages (from-to)	1160-1176.e24
Journal	Cell
Volume	179
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2019.10.027
Publication status	Published - 14 Nov 2019
Externally published	Yes

Keywords

CASP7
CD39
PDE4B
TNF
cAMP
dipyridamole
pediatric-onset colitis and IBD
platelet
risk genes
single-cell RNA expression

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10.1016/j.cell.2019.10.027

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Huang, B., Chen, Z., Geng, L., Wang, J., Liang, H., Cao, Y., Chen, H., Huang, W., Su, M., Wang, H., Xu, Y., Liu, Y., Lu, B., Xian, H., Li, H., Li, H., Ren, L., Xie, J., Ye, L., ... Zhang, Y. (2019). Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways. Cell, 179(5), 1160-1176.e24. https://doi.org/10.1016/j.cell.2019.10.027

@article{24f85ef8f58d492f82d2d67e1cba8b18,

title = "Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways",

abstract = "Single-cell and risk gene analysis of children with undifferentiated colitis, Crohn's disease, and ulcerative colitis identifies common underlying mechanisms of pathogenesis and reveals the potential therapeutic benefit of modulating cAMP signaling via the drug dipyridamole.",

keywords = "CASP7, CD39, PDE4B, TNF, cAMP, dipyridamole, pediatric-onset colitis and IBD, platelet, risk genes, single-cell RNA expression",

author = "Bing Huang and Zhanghua Chen and Lanlan Geng and Jun Wang and Huiying Liang and Yujie Cao and Huan Chen and Wanming Huang and Meiling Su and Hanqing Wang and Yanhui Xu and Yukun Liu and Bingtai Lu and Huifang Xian and Huiwen Li and Huilin Li and Lu Ren and Jing Xie and Liping Ye and Hongli Wang and Junhong Zhao and Peiyu Chen and Li Zhang and Shanmeizi Zhao and Ting Zhang and Banglao Xu and Di Che and Wenyue Si and Xiaoqiong Gu and Liang Zeng and Yong Wang and Dingyou Li and Yifan Zhan and David Delfouneso and Lew, {Andrew M.} and Jun Cui and Tang, {Wai Ho} and Yan Zhang and Sitang Gong and Fan Bai and Min Yang and Yuxia Zhang",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = nov,

day = "14",

doi = "10.1016/j.cell.2019.10.027",

language = "English",

volume = "179",

pages = "1160--1176.e24",

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Huang, B, Chen, Z, Geng, L, Wang, J, Liang, H, Cao, Y, Chen, H, Huang, W, Su, M, Wang, H, Xu, Y, Liu, Y, Lu, B, Xian, H, Li, H, Li, H, Ren, L, Xie, J, Ye, L, Wang, H, Zhao, J, Chen, P, Zhang, L, Zhao, S, Zhang, T, Xu, B, Che, D, Si, W, Gu, X, Zeng, L, Wang, Y, Li, D, Zhan, Y, Delfouneso, D, Lew, AM, Cui, J, Tang, WH, Zhang, Y, Gong, S, Bai, F, Yang, M & Zhang, Y 2019, 'Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways', Cell, vol. 179, no. 5, pp. 1160-1176.e24. https://doi.org/10.1016/j.cell.2019.10.027

TY - JOUR

T1 - Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

AU - Huang, Bing

AU - Chen, Zhanghua

AU - Geng, Lanlan

AU - Wang, Jun

AU - Liang, Huiying

AU - Cao, Yujie

AU - Chen, Huan

AU - Huang, Wanming

AU - Su, Meiling

AU - Wang, Hanqing

AU - Xu, Yanhui

AU - Liu, Yukun

AU - Lu, Bingtai

AU - Xian, Huifang

AU - Li, Huiwen

AU - Li, Huilin

AU - Ren, Lu

AU - Xie, Jing

AU - Ye, Liping

AU - Wang, Hongli

AU - Zhao, Junhong

AU - Chen, Peiyu

AU - Zhang, Li

AU - Zhao, Shanmeizi

AU - Zhang, Ting

AU - Xu, Banglao

AU - Che, Di

AU - Si, Wenyue

AU - Gu, Xiaoqiong

AU - Zeng, Liang

AU - Wang, Yong

AU - Li, Dingyou

AU - Zhan, Yifan

AU - Delfouneso, David

AU - Lew, Andrew M.

AU - Cui, Jun

AU - Tang, Wai Ho

AU - Zhang, Yan

AU - Gong, Sitang

AU - Bai, Fan

AU - Yang, Min

AU - Zhang, Yuxia

PY - 2019/11/14

Y1 - 2019/11/14

N2 - Single-cell and risk gene analysis of children with undifferentiated colitis, Crohn's disease, and ulcerative colitis identifies common underlying mechanisms of pathogenesis and reveals the potential therapeutic benefit of modulating cAMP signaling via the drug dipyridamole.

AB - Single-cell and risk gene analysis of children with undifferentiated colitis, Crohn's disease, and ulcerative colitis identifies common underlying mechanisms of pathogenesis and reveals the potential therapeutic benefit of modulating cAMP signaling via the drug dipyridamole.

KW - CASP7

KW - CD39

KW - PDE4B

KW - TNF

KW - cAMP

KW - dipyridamole

KW - pediatric-onset colitis and IBD

KW - platelet

KW - risk genes

KW - single-cell RNA expression

UR - http://www.scopus.com/inward/record.url?scp=85074719426&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.10.027

DO - 10.1016/j.cell.2019.10.027

M3 - Article

C2 - 31730855

AN - SCOPUS:85074719426

SN - 0092-8674

VL - 179

SP - 1160-1176.e24

JO - Cell

JF - Cell

IS - 5

ER -

Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

Abstract

Keywords

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