L-Asparagine on strontium hydroxyapatite nanorods morphology and biocompatibility

Raymond Wing Moon Lam; Chi Tak Wong; Zhao Yang Li; Keith Dip Kei Luk; Kenneth M.C. Cheung; Peter Kwong Yuen Chiu; Bing Xu; Wai Kin Chan; David Fang; John C.Y. Leong; William Weijia Lu

doi:10.1504/IJBET.2009.027795

L-Asparagine on strontium hydroxyapatite nanorods morphology and biocompatibility

Raymond Wing Moon Lam
, Chi Tak Wong
, Zhao Yang Li
, Keith Dip Kei Luk
, Kenneth M.C. Cheung
, Peter Kwong Yuen Chiu
, Bing Xu
, Wai Kin Chan
, David Fang
, John C.Y. Leong
, William Weijia Lu

Hong Kong Metropolitan University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In this study, we investigated the influence of L-Asparagine (L-Asn) on strontium hydroxyapatite (Sr-HA) nanorod morphology and their biocompatibility. Ammonia was used to adjust the pH of L-Asn Sr-HA precursor and was heated at 80-120°C for 5-15 h. From Transmission Electron Microscopy's (TEM) images, the lengths and diameters of the nanorod were 0.3901 ± 0.0804 μn and 30.4 ± 4.6 nm, respectively. L-Asn Sr-HA phosphate system provides a high phase purity of monodispersed strontium hydroxyapatite nanorod. From Live/Dead Assay, L-Asn Sr-HA nanorod showed cell-dependent cytotoxicity (SaOS-2<C2C12<L929) and these results have shown L-Asn Sr-HA nanorod can be adopted as fibrous tissue formation inhibitor.

Original language	English
Pages (from-to)	303-318
Number of pages	16
Journal	International Journal of Biomedical Engineering and Technology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1504/IJBET.2009.027795
Publication status	Published - Aug 2009

Keywords

Amino acid
Cytotoxicity
Strontium hydroxyapatite nanorod

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title = "L-Asparagine on strontium hydroxyapatite nanorods morphology and biocompatibility",

abstract = "In this study, we investigated the influence of L-Asparagine (L-Asn) on strontium hydroxyapatite (Sr-HA) nanorod morphology and their biocompatibility. Ammonia was used to adjust the pH of L-Asn Sr-HA precursor and was heated at 80-120°C for 5-15 h. From Transmission Electron Microscopy's (TEM) images, the lengths and diameters of the nanorod were 0.3901 ± 0.0804 μn and 30.4 ± 4.6 nm, respectively. L-Asn Sr-HA phosphate system provides a high phase purity of monodispersed strontium hydroxyapatite nanorod. From Live/Dead Assay, L-Asn Sr-HA nanorod showed cell-dependent cytotoxicity (SaOS-2",

keywords = "Amino acid, Cytotoxicity, Strontium hydroxyapatite nanorod",

author = "Lam, \{Raymond Wing Moon\} and Wong, \{Chi Tak\} and Li, \{Zhao Yang\} and Luk, \{Keith Dip Kei\} and Cheung, \{Kenneth M.C.\} and Chiu, \{Peter Kwong Yuen\} and Bing Xu and Chan, \{Wai Kin\} and David Fang and Leong, \{John C.Y.\} and Lu, \{William Weijia\}",

year = "2009",

month = aug,

doi = "10.1504/IJBET.2009.027795",

language = "English",

volume = "2",

pages = "303--318",

journal = "International Journal of Biomedical Engineering and Technology",

issn = "1752-6418",

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T1 - L-Asparagine on strontium hydroxyapatite nanorods morphology and biocompatibility

AU - Lam, Raymond Wing Moon

AU - Wong, Chi Tak

AU - Li, Zhao Yang

AU - Luk, Keith Dip Kei

AU - Cheung, Kenneth M.C.

AU - Chiu, Peter Kwong Yuen

AU - Xu, Bing

AU - Chan, Wai Kin

AU - Fang, David

AU - Leong, John C.Y.

AU - Lu, William Weijia

PY - 2009/8

Y1 - 2009/8

N2 - In this study, we investigated the influence of L-Asparagine (L-Asn) on strontium hydroxyapatite (Sr-HA) nanorod morphology and their biocompatibility. Ammonia was used to adjust the pH of L-Asn Sr-HA precursor and was heated at 80-120°C for 5-15 h. From Transmission Electron Microscopy's (TEM) images, the lengths and diameters of the nanorod were 0.3901 ± 0.0804 μn and 30.4 ± 4.6 nm, respectively. L-Asn Sr-HA phosphate system provides a high phase purity of monodispersed strontium hydroxyapatite nanorod. From Live/Dead Assay, L-Asn Sr-HA nanorod showed cell-dependent cytotoxicity (SaOS-2

AB - In this study, we investigated the influence of L-Asparagine (L-Asn) on strontium hydroxyapatite (Sr-HA) nanorod morphology and their biocompatibility. Ammonia was used to adjust the pH of L-Asn Sr-HA precursor and was heated at 80-120°C for 5-15 h. From Transmission Electron Microscopy's (TEM) images, the lengths and diameters of the nanorod were 0.3901 ± 0.0804 μn and 30.4 ± 4.6 nm, respectively. L-Asn Sr-HA phosphate system provides a high phase purity of monodispersed strontium hydroxyapatite nanorod. From Live/Dead Assay, L-Asn Sr-HA nanorod showed cell-dependent cytotoxicity (SaOS-2

KW - Amino acid

KW - Cytotoxicity

KW - Strontium hydroxyapatite nanorod

UR - https://www.scopus.com/pages/publications/78651540366

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DO - 10.1504/IJBET.2009.027795

M3 - Article

AN - SCOPUS:78651540366

SN - 1752-6418

VL - 2

SP - 303

EP - 318

JO - International Journal of Biomedical Engineering and Technology

JF - International Journal of Biomedical Engineering and Technology

IS - 4

ER -

L-Asparagine on strontium hydroxyapatite nanorods morphology and biocompatibility

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Keywords

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