@inproceedings{dc46cc045e3445c1a3946f79a4b9985b,
title = "Initial Investigation of C{\textendash}H Functionalization of Pentafluorobenzene with 2-Chloroquinoline Catalyzed by Palladium and Hemilabile Benzimidazolyl Phosphine Ligands",
abstract = "We report the first general examples of palladium-catalyzed C{\textendash}H functionalization of pentafluorobenzene with 2-chloroquinoline, enabled by a family of hemilabile benzimidazolyl phosphine ligands bearing tunable P,O or P,N coordination motifs. These ligands, designed to exhibit both soft (phosphorus) and hard (oxygen or nitrogen) donor atoms, offer dynamic binding properties that enhance catalytic performance under reaction conditions. Among the ligand variants investigated, the one featuring a {\textendash}Pt-Bu2 moiety and 5,6-dimethyl substitution on the benzimidazole ring demonstrated reasonable reactivity and efficiency with 1 mol\% Pd catalyst loading. This study highlights the potential of modularly designed hemilabile ligands in facilitating challenging C{\textendash}H functionalization reactions and provides a promising platform for further development of ligand-controlled catalytic systems.",
keywords = "Catalysis, C{\textendash}H Functionalization, Hemilabile, Palladium-Catalyzed",
author = "Wong, \{Shun Man\} and Ho, \{Wing Tung\}",
note = "Publisher Copyright: {\textcopyright} 2025, Avestia Publishing. All rights reserved.; 11th World Congress on Mechanical, Chemical, and Material Engineering, MCM 2025 ; Conference date: 19-08-2025 Through 21-08-2025",
year = "2025",
doi = "10.11159/iccpe25.138",
language = "English",
isbn = "9781990800603",
series = "Proceedings of the World Congress on Mechanical, Chemical, and Material Engineering",
editor = "Huihe Qiu and Yuwen Zhang and Marcello Iasiello",
booktitle = "Proceedings of the 11th World Congress on Mechanical, Chemical, and Material Engineering, MCM 2025",
}