TY - JOUR
T1 - Inflammation and atrial fibrillation
T2 - A comprehensive review
AU - Korantzopoulos, Panagiotis
AU - Letsas, Konstantinos P.
AU - Tse, Gary
AU - Fragakis, Nikolaos
AU - Goudis, Christos A.
AU - Liu, Tong
N1 - Publisher Copyright:
© 2018 The Authors.
PY - 2018/8
Y1 - 2018/8
N2 - Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves electrophysiological and structural abnormalities that promote the development and perpetuation of AF. Experimental and clinical data indicate that inflammation is implicated in the pathophysiology of atrial remodeling. The mechanistic links between atrial remodeling and inflammation are complex while diverse underlying diseases and conditions may affect these pathways. Inflammatory markers have also been associated with AF development, recurrence, perpetuation, total AF burden as well as with thromboembolic complications. The development of specific anti-inflammatory interventions in this setting seems to be challenging and complicated. Several agents with pleiotropic properties, including anti-inflammatory, have been tested in experimental and clinical settings with variable results. This updated review provides a concise overview of all available data regarding the role of inflammation in AF including the predictive role of inflammatory markers. Also, current knowledge and future directions on anti-inflammatory strategies are critically discussed.
AB - Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves electrophysiological and structural abnormalities that promote the development and perpetuation of AF. Experimental and clinical data indicate that inflammation is implicated in the pathophysiology of atrial remodeling. The mechanistic links between atrial remodeling and inflammation are complex while diverse underlying diseases and conditions may affect these pathways. Inflammatory markers have also been associated with AF development, recurrence, perpetuation, total AF burden as well as with thromboembolic complications. The development of specific anti-inflammatory interventions in this setting seems to be challenging and complicated. Several agents with pleiotropic properties, including anti-inflammatory, have been tested in experimental and clinical settings with variable results. This updated review provides a concise overview of all available data regarding the role of inflammation in AF including the predictive role of inflammatory markers. Also, current knowledge and future directions on anti-inflammatory strategies are critically discussed.
KW - Anti-inflammatory interventions
KW - Atrial fibrillation
KW - Atrial remodeling
KW - C-reactive protein
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=85054754755&partnerID=8YFLogxK
U2 - 10.1002/joa3.12077
DO - 10.1002/joa3.12077
M3 - Review article
AN - SCOPUS:85054754755
SN - 1880-4276
VL - 34
SP - 394
EP - 401
JO - Journal of Arrhythmia
JF - Journal of Arrhythmia
IS - 4
ER -