Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

X. Shu; J. Long; Q. Cai; S.-S. Kweon; J.-Y. Choi; M. Kubo; S.K. Park; M.K. Bolla; J. Dennis; Q. Wang; Y. Yang; J. Shi; X. Guo; B. Li; R. Tao; K.J. Aronson; K.Y.K. Chan; T.L. Chan; Y.-T. Gao; M. Hartman; W. Kee Ho; H. Ito; M. Iwasaki; H. Iwata; E.M. John; Y. Kasuga; U. Soon Khoo; M.-K. Kim; S.-Y. Kong; A.W. Kurian; A. Kwong; E.-S. Lee; J. Li; A. Lophatananon; S.-K. Low; S. Mariapun; K. Matsuda; K. Matsuo; K. Muir; D.-Y. Noh; B. Park; M.-H. Park; C.-Y. Shen; M.-H. Shin; J.J. Spinelli; A. Takahashi; C. Tseng; S. Tsugane; A.H. Wu; Y.-B. Xiang; T. Yamaji; Y. Zheng; R.L. Milne; A.M. Dunning; P.D.P. Pharoah; M. García-Closas; S.-H. Teo; X.-O. Shu; D. Kang; D.F. Easton; J. Simard; W. Zheng

doi:10.1038/s41467-020-15046-w

Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

X. Shu, J. Long, Q. Cai, S.-S. Kweon, J.-Y. Choi, M. Kubo, S.K. Park, M.K. Bolla, J. Dennis, Q. Wang, Y. Yang, J. Shi, X. Guo, B. Li, R. Tao, K.J. Aronson, K.Y.K. Chan, T.L. Chan, Y.-T. Gao, M. HartmanW. Kee Ho, H. Ito, M. Iwasaki, H. Iwata, E.M. John, Y. Kasuga, U. Soon Khoo, M.-K. Kim, S.-Y. Kong, A.W. Kurian, A. Kwong, E.-S. Lee, J. Li, A. Lophatananon, S.-K. Low, S. Mariapun, K. Matsuda, K. Matsuo, K. Muir, D.-Y. Noh, B. Park, M.-H. Park, C.-Y. Shen, M.-H. Shin, J.J. Spinelli, A. Takahashi, C. Tseng, S. Tsugane, A.H. Wu, Y.-B. Xiang, T. Yamaji, Y. Zheng, R.L. Milne, A.M. Dunning, P.D.P. Pharoah, M. García-Closas, S.-H. Teo, X.-O. Shu, D. Kang, D.F. Easton, J. Simard, W. Zheng

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Abstract

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.

Original language	English
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-15046-w
Publication status	Published - 2020
Externally published	Yes

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10.1038/s41467-020-15046-w

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Shu, X., Long, J., Cai, Q., Kweon, S.-S., Choi, J.-Y., Kubo, M., Park, S. K., Bolla, M. K., Dennis, J., Wang, Q., Yang, Y., Shi, J., Guo, X., Li, B., Tao, R., Aronson, K. J., Chan, K. Y. K., Chan, T. L., Gao, Y.-T., ... Zheng, W. (2020). Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-15046-w

@article{84eb5d38aa0e40c78dd3c29f06172016,

title = "Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants",

abstract = "Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.",

author = "X. Shu and J. Long and Q. Cai and S.-S. Kweon and J.-Y. Choi and M. Kubo and S.K. Park and M.K. Bolla and J. Dennis and Q. Wang and Y. Yang and J. Shi and X. Guo and B. Li and R. Tao and K.J. Aronson and K.Y.K. Chan and T.L. Chan and Y.-T. Gao and M. Hartman and {Kee Ho}, W. and H. Ito and M. Iwasaki and H. Iwata and E.M. John and Y. Kasuga and {Soon Khoo}, U. and M.-K. Kim and S.-Y. Kong and A.W. Kurian and A. Kwong and E.-S. Lee and J. Li and A. Lophatananon and S.-K. Low and S. Mariapun and K. Matsuda and K. Matsuo and K. Muir and D.-Y. Noh and B. Park and M.-H. Park and C.-Y. Shen and M.-H. Shin and J.J. Spinelli and A. Takahashi and C. Tseng and S. Tsugane and A.H. Wu and Y.-B. Xiang and T. Yamaji and Y. Zheng and R.L. Milne and A.M. Dunning and P.D.P. Pharoah and M. Garc{\'i}a-Closas and S.-H. Teo and X.-O. Shu and D. Kang and D.F. Easton and J. Simard and W. Zheng",

year = "2020",

doi = "10.1038/s41467-020-15046-w",

language = "English",

volume = "11",

number = "1",

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Shu, X, Long, J, Cai, Q, Kweon, S-S, Choi, J-Y, Kubo, M, Park, SK, Bolla, MK, Dennis, J, Wang, Q, Yang, Y, Shi, J, Guo, X, Li, B, Tao, R, Aronson, KJ, Chan, KYK, Chan, TL, Gao, Y-T, Hartman, M, Kee Ho, W, Ito, H, Iwasaki, M, Iwata, H, John, EM, Kasuga, Y, Soon Khoo, U, Kim, M-K, Kong, S-Y, Kurian, AW, Kwong, A, Lee, E-S, Li, J, Lophatananon, A, Low, S-K, Mariapun, S, Matsuda, K, Matsuo, K, Muir, K, Noh, D-Y, Park, B, Park, M-H, Shen, C-Y, Shin, M-H, Spinelli, JJ, Takahashi, A, Tseng, C, Tsugane, S, Wu, AH, Xiang, Y-B, Yamaji, T, Zheng, Y, Milne, RL, Dunning, AM, Pharoah, PDP, García-Closas, M, Teo, S-H, Shu, X-O, Kang, D, Easton, DF, Simard, J & Zheng, W 2020, 'Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants', Nature Communications, vol. 11, no. 1. https://doi.org/10.1038/s41467-020-15046-w

TY - JOUR

T1 - Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

AU - Shu, X.

AU - Long, J.

AU - Cai, Q.

AU - Kweon, S.-S.

AU - Choi, J.-Y.

AU - Kubo, M.

AU - Park, S.K.

AU - Bolla, M.K.

AU - Dennis, J.

AU - Wang, Q.

AU - Yang, Y.

AU - Shi, J.

AU - Guo, X.

AU - Li, B.

AU - Tao, R.

AU - Aronson, K.J.

AU - Chan, K.Y.K.

AU - Chan, T.L.

AU - Gao, Y.-T.

AU - Hartman, M.

AU - Kee Ho, W.

AU - Ito, H.

AU - Iwasaki, M.

AU - Iwata, H.

AU - John, E.M.

AU - Kasuga, Y.

AU - Soon Khoo, U.

AU - Kim, M.-K.

AU - Kong, S.-Y.

AU - Kurian, A.W.

AU - Kwong, A.

AU - Lee, E.-S.

AU - Li, J.

AU - Lophatananon, A.

AU - Low, S.-K.

AU - Mariapun, S.

AU - Matsuda, K.

AU - Matsuo, K.

AU - Muir, K.

AU - Noh, D.-Y.

AU - Park, B.

AU - Park, M.-H.

AU - Shen, C.-Y.

AU - Shin, M.-H.

AU - Spinelli, J.J.

AU - Takahashi, A.

AU - Tseng, C.

AU - Tsugane, S.

AU - Wu, A.H.

AU - Xiang, Y.-B.

AU - Yamaji, T.

AU - Zheng, Y.

AU - Milne, R.L.

AU - Dunning, A.M.

AU - Pharoah, P.D.P.

AU - García-Closas, M.

AU - Teo, S.-H.

AU - Shu, X.-O.

AU - Kang, D.

AU - Easton, D.F.

AU - Simard, J.

AU - Zheng, W.

PY - 2020

Y1 - 2020

N2 - Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.

AB - Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.

U2 - 10.1038/s41467-020-15046-w

DO - 10.1038/s41467-020-15046-w

M3 - Article

C2 - 32139696

VL - 11

JO - Nature Communications

JF - Nature Communications

IS - 1

ER -

Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Abstract

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