ICIs-Related Cardiotoxicity in Different Types of Cancer

Mei Dong, Ting Yu, Zhenzhen Zhang, Jing Zhang, Rujian Wang, Gary Tse, Tong Liu, Lin Zhong

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Immune checkpoint inhibitors (ICIs) are rapidly developing immunotherapy cancer drugs that have prolonged patient survival. However, ICIs-related cardiotoxicity has been recognized as a rare, but fatal, consequence. Although there has been extensive research based on different types of ICIs, these studies have not indicated whether cardiotoxicity is specific to a type of cancer. Therefore, we conducted a systematic review to analyze a variety of ICIs-related cardiotoxicity, focusing on different types of cancer. We found that the incidence of ICIs-related cardiac adverse events (CAEs) and common cardiotoxic manifestations vary with cancer type. This inspired us to explore the underlying mechanisms to formulate targeted clinical strategies for maintaining the cardiovascular health of cancer patients.

Original languageEnglish
Article number203
JournalJournal of Cardiovascular Development and Disease
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 2022
Externally publishedYes

Keywords

  • cancer-type-specific
  • cardio-oncology
  • cardiotoxicity
  • immune checkpoint inhibitors

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