TY - JOUR
T1 - Hypermethylation of SOX2 gene in hydatidiform mole and choriocarcinoma
AU - Li, A.S.M.
AU - Siu, M.K.Y.
AU - Zhang, H.
AU - Wong, E.S.Y.
AU - Chan, K.Y.K.
AU - Ngan, H.Y.S.
AU - Cheung, A.N.Y.
PY - 2008
Y1 - 2008
N2 - This study investigated the expression and methylation profiles of SOX2, a stem cell-related transcription factor, in placentas and gestational trophoblastic disease. The methylation status of SOX2 promoter region in 55 hydatidiform moles, 4 choriocarcinoma, 23 first trimester, and 15 term placentas was evaluated by methylation-specific polymerase chain reaction. The methylated allele was found in 4.4% (1/23) of first trimester placentas, 26.7% (4/15) term placentas, and 56.4% (31/55) of hydatidiform moles and all choriocarcinoma samples and cell lines. A significant reduction in SOX2 messenger RNA expression was found in the hydatidiform moles (P =.027) when compared with that in the placentas. SOX2 messenger RNA expression was significantly correlated with SOX2 hypermethylation (P
AB - This study investigated the expression and methylation profiles of SOX2, a stem cell-related transcription factor, in placentas and gestational trophoblastic disease. The methylation status of SOX2 promoter region in 55 hydatidiform moles, 4 choriocarcinoma, 23 first trimester, and 15 term placentas was evaluated by methylation-specific polymerase chain reaction. The methylated allele was found in 4.4% (1/23) of first trimester placentas, 26.7% (4/15) term placentas, and 56.4% (31/55) of hydatidiform moles and all choriocarcinoma samples and cell lines. A significant reduction in SOX2 messenger RNA expression was found in the hydatidiform moles (P =.027) when compared with that in the placentas. SOX2 messenger RNA expression was significantly correlated with SOX2 hypermethylation (P
KW - Choriocarcinoma
KW - Hydatidiform mole
KW - Methylation
KW - Placenta
KW - SOX2
U2 - 10.1177/1933719108322433
DO - 10.1177/1933719108322433
M3 - Article
C2 - 18836133
VL - 15
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 7
ER -