Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

V.S.F. Chan; K.Y.K. Chan; Y. Chen; L.L.M. Poon; A.N.Y. Cheung; B. Zheng; K.-H. Chan; W. Mak; H.Y.S. Ngan; X. Xu; G. Screaton; P.K.H. Tam; J.M. Austyn; L.-C. Chan; S.-P. Yip; M. Peiris; U.-S. Khoo; C.-L.S. Lin

doi:10.1038/ng1698

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

V.S.F. Chan, K.Y.K. Chan, Y. Chen, L.L.M. Poon, A.N.Y. Cheung, B. Zheng, K.-H. Chan, W. Mak, H.Y.S. Ngan, X. Xu, G. Screaton, P.K.H. Tam, J.M. Austyn, L.-C. Chan, S.-P. Yip, M. Peiris, U.-S. Khoo, C.-L.S. Lin

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Abstract

Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection. © 2006 Nature Publishing Group.

Original language	English
Journal	Nature Genetics
Volume	38
Issue number	1
DOIs	https://doi.org/10.1038/ng1698
Publication status	Published - 2006
Externally published	Yes

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Chan, V. S. F., Chan, K. Y. K., Chen, Y., Poon, L. L. M., Cheung, A. N. Y., Zheng, B., Chan, K.-H., Mak, W., Ngan, H. Y. S., Xu, X., Screaton, G., Tam, P. K. H., Austyn, J. M., Chan, L.-C., Yip, S.-P., Peiris, M., Khoo, U.-S., & Lin, C.-LS. (2006). Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nature Genetics, 38(1). https://doi.org/10.1038/ng1698

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title = "Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection",

abstract = "Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection. {\textcopyright} 2006 Nature Publishing Group.",

author = "V.S.F. Chan and K.Y.K. Chan and Y. Chen and L.L.M. Poon and A.N.Y. Cheung and B. Zheng and K.-H. Chan and W. Mak and H.Y.S. Ngan and X. Xu and G. Screaton and P.K.H. Tam and J.M. Austyn and L.-C. Chan and S.-P. Yip and M. Peiris and U.-S. Khoo and C.-L.S. Lin",

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T1 - Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

AU - Chan, V.S.F.

AU - Chan, K.Y.K.

AU - Chen, Y.

AU - Poon, L.L.M.

AU - Cheung, A.N.Y.

AU - Zheng, B.

AU - Chan, K.-H.

AU - Mak, W.

AU - Ngan, H.Y.S.

AU - Xu, X.

AU - Screaton, G.

AU - Tam, P.K.H.

AU - Austyn, J.M.

AU - Chan, L.-C.

AU - Yip, S.-P.

AU - Peiris, M.

AU - Khoo, U.-S.

AU - Lin, C.-L.S.

PY - 2006

Y1 - 2006

N2 - Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection. © 2006 Nature Publishing Group.

AB - Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection. © 2006 Nature Publishing Group.

U2 - 10.1038/ng1698

DO - 10.1038/ng1698

M3 - Article

C2 - 16369534

VL - 38

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

Abstract

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