TY - JOUR
T1 - Glucose-6-phosphate dehydrogenase deficiency and metabolic profiling in adolescence from the Chinese birth cohort
T2 - “Children of 1997”
AU - Kwok, Man Ki
AU - Leung, Gabriel M.
AU - Au Yeung, Shiu Lun
AU - Schooling, C. Mary
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/4/15
Y1 - 2019/4/15
N2 - Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency affects 6.0% of the global population. G6PD deficiency has been associated with lower risk of cardiovascular disease and higher risk of diabetes, which could be etiologically informative, but these relations are uncertain. To clarify, we assessed the associations of G6PD deficiency with serum metabolite profiles in late adolescence. Methods: In a nested case-control study of 50 G6PD-deficient late adolescents (~17.5 years) and 150 sex-matched non-G6PD-deficient controls from a Chinese birth cohort: “Children of 1997”, we compared 80 serum metabolites analyzed by nuclear magnetic resonance spectrometry using adjusted linear regression with Bonferroni correction for testing 12 traits (p < 0.0042). Results: G6PD-deficiency was inversely associated with serum levels of total cholesterol (−0.27 mmol, 95% confidence interval (CI) −0.46, −0.09, p = 0.004), free cholesterol (−0.08 mmol, 95% CI −0.13, −0.03, p = 0.003) and creatinine (−0.004 mmol, 95% CI −0.007, −0.001, p = 0.003), adjusted for sex and parental education. G6PD deficiency was not associated with fatty acids, amino acids, glucose or related metabolites, ketone bodies or glycoprotein. Conclusions: G6PD deficiency is associated with lower serum levels of cholesterol and creatinine, but not other serum metabolites. Whether such differences are transient or become more evident in adulthood warrant further investigations.
AB - Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency affects 6.0% of the global population. G6PD deficiency has been associated with lower risk of cardiovascular disease and higher risk of diabetes, which could be etiologically informative, but these relations are uncertain. To clarify, we assessed the associations of G6PD deficiency with serum metabolite profiles in late adolescence. Methods: In a nested case-control study of 50 G6PD-deficient late adolescents (~17.5 years) and 150 sex-matched non-G6PD-deficient controls from a Chinese birth cohort: “Children of 1997”, we compared 80 serum metabolites analyzed by nuclear magnetic resonance spectrometry using adjusted linear regression with Bonferroni correction for testing 12 traits (p < 0.0042). Results: G6PD-deficiency was inversely associated with serum levels of total cholesterol (−0.27 mmol, 95% confidence interval (CI) −0.46, −0.09, p = 0.004), free cholesterol (−0.08 mmol, 95% CI −0.13, −0.03, p = 0.003) and creatinine (−0.004 mmol, 95% CI −0.007, −0.001, p = 0.003), adjusted for sex and parental education. G6PD deficiency was not associated with fatty acids, amino acids, glucose or related metabolites, ketone bodies or glycoprotein. Conclusions: G6PD deficiency is associated with lower serum levels of cholesterol and creatinine, but not other serum metabolites. Whether such differences are transient or become more evident in adulthood warrant further investigations.
KW - Adolescence
KW - Cardiovascular disease risk factors
KW - Cohort studies
KW - G6PD deficiency
KW - Metabolomics
UR - http://www.scopus.com/inward/record.url?scp=85061092893&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2019.01.100
DO - 10.1016/j.ijcard.2019.01.100
M3 - Article
C2 - 30739801
AN - SCOPUS:85061092893
SN - 0167-5273
VL - 281
SP - 146
EP - 149
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -