TY - JOUR
T1 - Electrocardiographic Features of Immune Checkpoint Inhibitor-Associated Myocarditis
AU - Song, Wenhua
AU - Zheng, Yi
AU - Dong, Mei
AU - Zhong, Lin
AU - Bazoukis, George
AU - Perone, Francesco
AU - Li, Guangping
AU - Ng, Chi Fai
AU - Baranchuk, Adrian
AU - Tse, Gary
AU - Liu, Tong
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2023/2
Y1 - 2023/2
N2 - Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events including myocarditis, whilst improving cancer-related outcomes. There is thus a clinical need to identify electrocardiographic manifestations of ICI-related myocarditis to guide clinical management. PubMed was searched for clinical studies and case reports describing electrocardiographic changes in patients with ICI-related myocarditis. A total of 6 clinical studies and 79 case reports were included. This revealed a range of presentations for patients on ICIs, including supraventricular arrhythmias, ventricular arrhythmias and heart block, and new changes of ST-T segment unrelated to coronary artery disease, ST-segment elevation or depression and T-wave abnormalities. Several patients showed low voltages in multiple leads and new onset Q-wave development. Patients with ICI-related myocarditis may develop new arrhythmia and ST-T changes, and infrequently low voltages in multiple leads.
AB - Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events including myocarditis, whilst improving cancer-related outcomes. There is thus a clinical need to identify electrocardiographic manifestations of ICI-related myocarditis to guide clinical management. PubMed was searched for clinical studies and case reports describing electrocardiographic changes in patients with ICI-related myocarditis. A total of 6 clinical studies and 79 case reports were included. This revealed a range of presentations for patients on ICIs, including supraventricular arrhythmias, ventricular arrhythmias and heart block, and new changes of ST-T segment unrelated to coronary artery disease, ST-segment elevation or depression and T-wave abnormalities. Several patients showed low voltages in multiple leads and new onset Q-wave development. Patients with ICI-related myocarditis may develop new arrhythmia and ST-T changes, and infrequently low voltages in multiple leads.
UR - http://www.scopus.com/inward/record.url?scp=85142203910&partnerID=8YFLogxK
U2 - 10.1016/j.cpcardiol.2022.101478
DO - 10.1016/j.cpcardiol.2022.101478
M3 - Review article
C2 - 36336121
AN - SCOPUS:85142203910
SN - 0146-2806
VL - 48
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 2
M1 - 101478
ER -