Electrocardiographic Features of Immune Checkpoint Inhibitor-Associated Myocarditis

Wenhua Song, Yi Zheng, Mei Dong, Lin Zhong, George Bazoukis, Francesco Perone, Guangping Li, Chi Fai Ng, Adrian Baranchuk, Gary Tse, Tong Liu

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events including myocarditis, whilst improving cancer-related outcomes. There is thus a clinical need to identify electrocardiographic manifestations of ICI-related myocarditis to guide clinical management. PubMed was searched for clinical studies and case reports describing electrocardiographic changes in patients with ICI-related myocarditis. A total of 6 clinical studies and 79 case reports were included. This revealed a range of presentations for patients on ICIs, including supraventricular arrhythmias, ventricular arrhythmias and heart block, and new changes of ST-T segment unrelated to coronary artery disease, ST-segment elevation or depression and T-wave abnormalities. Several patients showed low voltages in multiple leads and new onset Q-wave development. Patients with ICI-related myocarditis may develop new arrhythmia and ST-T changes, and infrequently low voltages in multiple leads.

Original languageEnglish
Article number101478
JournalCurrent Problems in Cardiology
Volume48
Issue number2
DOIs
Publication statusPublished - Feb 2023
Externally publishedYes

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