Electrocardiographic evidence of abnormal atrial phenotype in Brugada syndrome

Background: Brugada syndrome (BrS)is an inherited ion channelopathy that may predispose affected individuals to atrial cardiomyopathy. We tested the hypothesis that BrS patients have higher degrees of atrial electrophysiological abnormalities compared to controls, and these can be reflected by changes in P-wave parameters determined on the electrocardiogram (ECG). Methods: This was a single-center retrospective study comparing BrS patients to age- and gender-matched control subjects. Mean P-wave duration (PWD_mean), maximum PWD (PWD_max)and minimum PWD (PWD_min), P-wave dispersion (PWD_max – PWD_min), and P-wave terminal force in V1 (PTFV1)were measured. PWD_max ≥ 120 ms, in the presence and absence of biphasic P-waves in the inferior leads, were termed advanced and partial inter-atrial block (IAB), respectively. Results: The proportion of IAB was significantly higher in BrS patients (28/51; 55%)than in control subjects (14/51; 27%; Fisher's Exact test; P < 0.01). Advanced IAB was observed in two BrS patients but none of the control subjects (P = 0.50). Compared to controls, BrS patients showed higher PWD_mean (107 [98–113]vs. 97 [90–108]ms; KWANOVA, P < 0.01), PWD_max (123 [110–132]vs. 113 [107–121]ms; P < 0.001)but statistically indistinguishable PWD_min (82 [72–92]vs. 77 [69–85]; P = 0.09), and P-wave dispersion (38 [26–52]vs. 37 [23–45]ms; P = 0.14). PTFV1 was significantly higher in BrS patients than in control subjects (24 [0–40]vs. 0 [0–27]mm.ms; P < 0.05). Conclusion: Atrial conduction abnormalities are frequently observed in BrS. These patients may require monitoring for future development of atrial fibrillation and stroke.