Effects of echinocandins in combination with nikkomycin Z against invasive candida albicans bloodstream isolates and the fks mutants

Yuk Yam Cheung; Mamie Hui

doi:10.1128/AAC.00619-17

Effects of echinocandins in combination with nikkomycin Z against invasive candida albicans bloodstream isolates and the fks mutants

Yuk Yam Cheung
, Mamie Hui

Diagnostic Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

We evaluated the in vitro and in vivo effects of nikkomycin Z combined with an echinocandin (anidulafungin or micafungin) against two Candida albicans isolates and their lab-derived echinocandin-resistant fks mutants with FKS1 S645Y and FKS1 S645P. Synergistic effects were observed in all tested strains (fractional inhibitory concentration index, 0.5). Enhanced survival was observed in an immuno-compromised murine model (log-rank test, P 0.02). Our study demonstrated the therapeutic potential of nikkomycin Z-echinocandin combinations in managing echinocandin resistance.

Original language	English
Article number	e00619-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00619-17
Publication status	Published - Nov 2017

Keywords

Candida albicans
Echinocandin
FKS
Nikkomycin Z

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00619-17

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title = "Effects of echinocandins in combination with nikkomycin Z against invasive candida albicans bloodstream isolates and the fks mutants",

abstract = "We evaluated the in vitro and in vivo effects of nikkomycin Z combined with an echinocandin (anidulafungin or micafungin) against two Candida albicans isolates and their lab-derived echinocandin-resistant fks mutants with FKS1 S645Y and FKS1 S645P. Synergistic effects were observed in all tested strains (fractional inhibitory concentration index, 0.5). Enhanced survival was observed in an immuno-compromised murine model (log-rank test, P 0.02). Our study demonstrated the therapeutic potential of nikkomycin Z-echinocandin combinations in managing echinocandin resistance.",

keywords = "Candida albicans, Echinocandin, FKS, Nikkomycin Z",

author = "Cheung, \{Yuk Yam\} and Mamie Hui",

note = "Publisher Copyright: Copyright {\textcopyright} 2017 Cheung and Hui.",

year = "2017",

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doi = "10.1128/AAC.00619-17",

language = "English",

volume = "61",

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AU - Cheung, Yuk Yam

AU - Hui, Mamie

PY - 2017/11

Y1 - 2017/11

N2 - We evaluated the in vitro and in vivo effects of nikkomycin Z combined with an echinocandin (anidulafungin or micafungin) against two Candida albicans isolates and their lab-derived echinocandin-resistant fks mutants with FKS1 S645Y and FKS1 S645P. Synergistic effects were observed in all tested strains (fractional inhibitory concentration index, 0.5). Enhanced survival was observed in an immuno-compromised murine model (log-rank test, P 0.02). Our study demonstrated the therapeutic potential of nikkomycin Z-echinocandin combinations in managing echinocandin resistance.

AB - We evaluated the in vitro and in vivo effects of nikkomycin Z combined with an echinocandin (anidulafungin or micafungin) against two Candida albicans isolates and their lab-derived echinocandin-resistant fks mutants with FKS1 S645Y and FKS1 S645P. Synergistic effects were observed in all tested strains (fractional inhibitory concentration index, 0.5). Enhanced survival was observed in an immuno-compromised murine model (log-rank test, P 0.02). Our study demonstrated the therapeutic potential of nikkomycin Z-echinocandin combinations in managing echinocandin resistance.

KW - Candida albicans

KW - Echinocandin

KW - FKS

KW - Nikkomycin Z

UR - https://www.scopus.com/pages/publications/85032503373

U2 - 10.1128/AAC.00619-17

DO - 10.1128/AAC.00619-17

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AN - SCOPUS:85032503373

SN - 0066-4804

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

M1 - e00619-17

ER -

Effects of echinocandins in combination with nikkomycin Z against invasive candida albicans bloodstream isolates and the fks mutants

Abstract

Keywords

UN SDGs

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