Effects of alpha particles on zebrafish embryos

E. H.W. Yum; V. W.T. Li; V. W.Y. Choi; S. H. Cheng; K. N. Yu

doi:10.1016/j.apradiso.2009.09.035

Effects of alpha particles on zebrafish embryos

E. H.W. Yum
, V. W.T. Li
, V. W.Y. Choi
, S. H. Cheng
, K. N. Yu

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Dechorionated zebrafish embryos were irradiated at 1.5 h post fertilization (hpf) to low-doses of alpha particles, viz., 1.4, 2.8, 5.6, 11.2 mGy (determined using Monte Carlo simulations). At 24 hpf, these embryos were then examined for apoptotic cells through acridine orange staining. The mean number of apoptotic cells was found to decrease significantly from controls to 1.4-mGy irradiation, and then to increase almost linearly to 2.8, 5.6 and 11.2-mGy irradiation. This trend is a typical characteristic of a hormetic effect.

Original language	English
Pages (from-to)	714-717
Number of pages	4
Journal	Applied Radiation and Isotopes
Volume	68
Issue number	4-5
DOIs	https://doi.org/10.1016/j.apradiso.2009.09.035
Publication status	Published - Apr 2010
Externally published	Yes

Keywords

Alpha particles
Hormetic effect
Radiation hormesis
Zebrafish embryos

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10.1016/j.apradiso.2009.09.035

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title = "Effects of alpha particles on zebrafish embryos",

abstract = "Dechorionated zebrafish embryos were irradiated at 1.5 h post fertilization (hpf) to low-doses of alpha particles, viz., 1.4, 2.8, 5.6, 11.2 mGy (determined using Monte Carlo simulations). At 24 hpf, these embryos were then examined for apoptotic cells through acridine orange staining. The mean number of apoptotic cells was found to decrease significantly from controls to 1.4-mGy irradiation, and then to increase almost linearly to 2.8, 5.6 and 11.2-mGy irradiation. This trend is a typical characteristic of a hormetic effect.",

keywords = "Alpha particles, Hormetic effect, Radiation hormesis, Zebrafish embryos",

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AU - Yum, E. H.W.

AU - Li, V. W.T.

AU - Choi, V. W.Y.

AU - Cheng, S. H.

AU - Yu, K. N.

PY - 2010/4

Y1 - 2010/4

N2 - Dechorionated zebrafish embryos were irradiated at 1.5 h post fertilization (hpf) to low-doses of alpha particles, viz., 1.4, 2.8, 5.6, 11.2 mGy (determined using Monte Carlo simulations). At 24 hpf, these embryos were then examined for apoptotic cells through acridine orange staining. The mean number of apoptotic cells was found to decrease significantly from controls to 1.4-mGy irradiation, and then to increase almost linearly to 2.8, 5.6 and 11.2-mGy irradiation. This trend is a typical characteristic of a hormetic effect.

AB - Dechorionated zebrafish embryos were irradiated at 1.5 h post fertilization (hpf) to low-doses of alpha particles, viz., 1.4, 2.8, 5.6, 11.2 mGy (determined using Monte Carlo simulations). At 24 hpf, these embryos were then examined for apoptotic cells through acridine orange staining. The mean number of apoptotic cells was found to decrease significantly from controls to 1.4-mGy irradiation, and then to increase almost linearly to 2.8, 5.6 and 11.2-mGy irradiation. This trend is a typical characteristic of a hormetic effect.

KW - Alpha particles

KW - Hormetic effect

KW - Radiation hormesis

KW - Zebrafish embryos

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SP - 714

EP - 717

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 4-5

ER -

Effects of alpha particles on zebrafish embryos

Abstract

Keywords

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