TY - JOUR
T1 - Disease burden of Clostridium difficile infections in adults, Hong Kong, China, 2006–2014
AU - Ho, Jeffery
AU - Dai, Rudin Z.W.
AU - Kwong, Thomas N.Y.
AU - Wang, Xiansong
AU - Zhang, Lin
AU - Ip, Margaret
AU - Chan, Raphael
AU - Hawkey, Peter M.K.
AU - Lam, Kelvin L.Y.
AU - Wong, Martin C.S.
AU - Tse, Gary
AU - Chan, Matthew T.V.
AU - Chan, Francis K.L.
AU - Yu, Jun
AU - Ng, Siew C.
AU - Lee, Nelson
AU - Wu, Justin C.Y.
AU - Sung, Joseph J.Y.
AU - Wu, William K.K.
AU - Wong, Sunny H.
N1 - Publisher Copyright:
© 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2017/10
Y1 - 2017/10
N2 - Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5.1%) community-associated cases. After adjustment for diagnostic test, we found that incidence increased from 15.41 cases/100,000 persons in 2006 to 36.31 cases/100,000 persons in 2014, an annual increase of 26%. This increase was associated with elderly patients, for whom incidence increased 3-fold over the period. Recurrence at 60 days increased from 5.7% in 2006 to 9.1% in 2014 (p<0.001). Our data suggest the need for further surveillance, especially in Asia, which contains ≈60% of the world’s population.
AB - Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5.1%) community-associated cases. After adjustment for diagnostic test, we found that incidence increased from 15.41 cases/100,000 persons in 2006 to 36.31 cases/100,000 persons in 2014, an annual increase of 26%. This increase was associated with elderly patients, for whom incidence increased 3-fold over the period. Recurrence at 60 days increased from 5.7% in 2006 to 9.1% in 2014 (p<0.001). Our data suggest the need for further surveillance, especially in Asia, which contains ≈60% of the world’s population.
UR - https://www.scopus.com/pages/publications/85029742047
U2 - 10.3201/eid2310.170797
DO - 10.3201/eid2310.170797
M3 - Article
C2 - 28930010
AN - SCOPUS:85029742047
SN - 1080-6040
VL - 23
SP - 1671
EP - 1679
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 10
ER -
