Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Jiaqi Liu; Chi Tim Leung; Luyun Liang; Yuqin Wang; Jian Chen; Keng Po Lai; William Ka Fai Tse

doi:10.3390/cancers14143547

Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Jiaqi Liu, Chi Tim Leung, Luyun Liang, Yuqin Wang, Jian Chen, Keng Po Lai, William Ka Fai Tse

Applied Science

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.

Original language	English
Article number	3547
Number of pages	24
Journal	Cancers
Volume	14
Issue number	14
DOIs	https://doi.org/10.3390/cancers14143547 https://doi.org/10.3390/cancers14143547
Publication status	Published - Jul 2022

Keywords

apoptosis
metastasis
proliferation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis",

abstract = "Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.",

keywords = "apoptosis, metastasis, proliferation",

author = "Jiaqi Liu and Leung, {Chi Tim} and Luyun Liang and Yuqin Wang and Jian Chen and Lai, {Keng Po} and Tse, {William Ka Fai}",

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volume = "14",

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T1 - Deubiquitinases in Cancers

T2 - Aspects of Proliferation, Metastasis, and Apoptosis

AU - Liu, Jiaqi

AU - Leung, Chi Tim

AU - Liang, Luyun

AU - Wang, Yuqin

AU - Chen, Jian

AU - Lai, Keng Po

AU - Tse, William Ka Fai

PY - 2022/7

Y1 - 2022/7

N2 - Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.

AB - Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.

KW - apoptosis

KW - metastasis

KW - proliferation

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U2 - 10.3390/cancers14143547

DO - 10.3390/cancers14143547

M3 - Review article

C2 - 35884607

VL - 14

JO - Cancers

JF - Cancers

IS - 14

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ER -

Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Abstract

Keywords

UN SDGs

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