Ce-Mn-Doped Mesoporous Silica Nanomaterials for Psoriasis Treatment Based on Reactive Oxygen Species Scavenging

Psoriasis is a prevalent chronic inflammatory disorder affecting approximately 0.72% of the Chinese population. Currently, available treatments cannot completely cure this disease. The excessive production of reactive oxygen species (ROS) has been considered to be a key contributor to the progression of psoriasis. In this study, Ce and Mn were doped into mesoporous silicon nanomaterials with optimized ratios that could form uniform and well-dispersed CM@MSNs particles, which were able to effectively remove a wide range of ROS. As a result, treatment with CM@MSNs could reduce epidermal hyperplasia and prevent inflammatory reactions in the imiquimod (IMQ)-induced psoriasis-like model in mice. Mechanistically, CM@MSNs might prevent the inflammation by repressing the IL-17 and NF-κB signaling pathways and ameliorating epidermal hyperplasia through the activation of both canonical and noncanonical Wnt signaling pathways. In conclusion, this research could lead to a promising treatment method for psoriasis. This work provides an example of nanoenzymes for effectively scavenging ROS of diseases.