TY - JOUR
T1 - Cancer antigen-125 and risk of atrial fibrillation
T2 - A systematic review and meta-analysis
AU - Cheung, Angel
AU - Gong, Mengqi
AU - Bellanti, Roberto
AU - Ali-Hasan-Al-Saegh, Sadeq
AU - Li, Guangping
AU - Roig, Eulàlia
AU - Núñez, Julio
AU - Stamos, Thomas D.
AU - Yilmaz, Mehmet Birhan
AU - Hakki, Kaya
AU - Wu, William K.K.
AU - Wong, Sunny Hei
AU - Wong, Wing Tak
AU - Bazoukis, George
AU - Lampropoulos, Konstantinos
AU - Tse, Lah Ah
AU - Zhao, Jichao
AU - Lip, Gregory Y.H.
AU - Baranchuk, Adrian
AU - Wong, Martin C.S.
AU - Liu, Tong
AU - Tse, Gary
N1 - Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved.
PY - 2018/1
Y1 - 2018/1
N2 - Background Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF. Methods PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels. Results A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I2: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I2: 84%). Conclusion Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.
AB - Background Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF. Methods PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels. Results A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I2: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I2: 84%). Conclusion Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.
UR - https://www.scopus.com/pages/publications/85041553016
U2 - 10.1136/heartasia-2017-010970
DO - 10.1136/heartasia-2017-010970
M3 - Article
AN - SCOPUS:85041553016
VL - 10
JO - Heart Asia
JF - Heart Asia
IS - 1
M1 - 010970
ER -
