TY - JOUR
T1 - Biochemical pancreatic 13-cell lineage reprogramming
T2 - Various cell fate shifts
AU - Wang, Yuqin
AU - Liu, Zhuoqing
AU - Li, Shengren
AU - Su, Xuejuan
AU - Lai, Keng Po
AU - Li, Rong
N1 - Publisher Copyright:
© 2023 Elsevier Masson SAS
PY - 2024/3
Y1 - 2024/3
N2 - The incidence of pancreatic diseases has been continuously rising in recent years. Thus, research on pancreatic regeneration is becoming more popular. Chronic hyperglycemia is detrimental to pancreatic β-cells, leading to impairment of insulin secretion which is the main hallmark of pancreatic diseases. Obtaining plenty of functional pancreatic β-cells is the most crucial aspect when studying pancreatic biology and treating diabetes. According to the International Diabetes Federation, diabetes has become a global epidemic, with about 3 million people suffering from diabetes worldwide. Hyperglycemia can lead to many dangerous diseases, including amputation, blindness, neuropathy, stroke, and cardiovascular and kidney diseases. Insulin is widely used in the treatment of diabetes; however, innovative approaches are needed in the academic and preclinical stages. A new approach aims at synthesizing patient-specific functional pancreatic β-cells. The present article focuses on how cells from different tissues can be transformed into pancreatic β-cells.
AB - The incidence of pancreatic diseases has been continuously rising in recent years. Thus, research on pancreatic regeneration is becoming more popular. Chronic hyperglycemia is detrimental to pancreatic β-cells, leading to impairment of insulin secretion which is the main hallmark of pancreatic diseases. Obtaining plenty of functional pancreatic β-cells is the most crucial aspect when studying pancreatic biology and treating diabetes. According to the International Diabetes Federation, diabetes has become a global epidemic, with about 3 million people suffering from diabetes worldwide. Hyperglycemia can lead to many dangerous diseases, including amputation, blindness, neuropathy, stroke, and cardiovascular and kidney diseases. Insulin is widely used in the treatment of diabetes; however, innovative approaches are needed in the academic and preclinical stages. A new approach aims at synthesizing patient-specific functional pancreatic β-cells. The present article focuses on how cells from different tissues can be transformed into pancreatic β-cells.
KW - Cell fate shifts
KW - Pancreatic 13-cells
KW - Reprogramming
KW - Transdifferentiation
UR - http://www.scopus.com/inward/record.url?scp=85183543225&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/be5b9eda-3b13-3593-ab51-6c7fdd1c95ab/
U2 - 10.1016/j.retram.2023.103412
DO - 10.1016/j.retram.2023.103412
M3 - Review article
C2 - 38246021
VL - 72
JO - Current Research in Translational Medicine
JF - Current Research in Translational Medicine
IS - 1
M1 - 103412
ER -
