Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

You Qiang Song; Kenneth M.C. Cheung; Daniel W.H. Ho; Sandy C.S. Poon; Kazuhiro Chiba; Yoshiharu Kawaguchi; Yuichiro Hirose; Mauro Alini; Sibylle Grad; Anita F.Y. Yee; John C C.Y. Leong; Keith D.K. Luk; Shea Ping Yip; Jaro Karppinen; Kathryn S.E. Cheah; Pak Sham; Shiro Ikegawa; Danny Chan

doi:10.1016/j.ajhg.2007.12.017

Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

You Qiang Song, Kenneth M.C. Cheung, Daniel W.H. Ho, Sandy C.S. Poon, Kazuhiro Chiba, Yoshiharu Kawaguchi, Yuichiro Hirose, Mauro Alini, Sibylle Grad, Anita F.Y. Yee, John C C.Y. Leong, Keith D.K. Luk, Shea Ping Yip, Jaro Karppinen, Kathryn S.E. Cheah, Pak Sham, Shiro Ikegawa, Danny Chan

Hong Kong Metropolitan University

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.

Original language	English
Pages (from-to)	744-747
Number of pages	4
Journal	American Journal of Human Genetics
Volume	82
Issue number	3
DOIs	https://doi.org/10.1016/j.ajhg.2007.12.017
Publication status	Published - 3 Mar 2008

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Song, Y. Q., Cheung, K. M. C., Ho, D. W. H., Poon, S. C. S., Chiba, K., Kawaguchi, Y., Hirose, Y., Alini, M., Grad, S., Yee, A. F. Y., Leong, JC. C. Y., Luk, K. D. K., Yip, S. P., Karppinen, J., Cheah, K. S. E., Sham, P., Ikegawa, S., & Chan, D. (2008). Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians. American Journal of Human Genetics, 82(3), 744-747. https://doi.org/10.1016/j.ajhg.2007.12.017

@article{936ac3fc462b423fb1d5b73a17ae7c2a,

title = "Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians",

abstract = "Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.",

author = "Song, \{You Qiang\} and Cheung, \{Kenneth M.C.\} and Ho, \{Daniel W.H.\} and Poon, \{Sandy C.S.\} and Kazuhiro Chiba and Yoshiharu Kawaguchi and Yuichiro Hirose and Mauro Alini and Sibylle Grad and Yee, \{Anita F.Y.\} and Leong, \{John C C.Y.\} and Luk, \{Keith D.K.\} and Yip, \{Shea Ping\} and Jaro Karppinen and Cheah, \{Kathryn S.E.\} and Pak Sham and Shiro Ikegawa and Danny Chan",

note = "Funding Information: We thank Ms. Pei Yu for coordinating blood collection and assistance in MRI and questionnaire acquisition. This work was supported by grants from the University Grants Committee of Hong Kong (AoE/M-04/04) and grant-in-aid from Ministry of Education, Culture, Sports and Science of Japan (Contract grant number: 19209049).",

year = "2008",

month = mar,

day = "3",

doi = "10.1016/j.ajhg.2007.12.017",

language = "English",

volume = "82",

pages = "744--747",

journal = "American Journal of Human Genetics",

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publisher = "Cell Press",

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Song, YQ, Cheung, KMC, Ho, DWH, Poon, SCS, Chiba, K, Kawaguchi, Y, Hirose, Y, Alini, M, Grad, S, Yee, AFY, Leong, JCCY, Luk, KDK, Yip, SP, Karppinen, J, Cheah, KSE, Sham, P, Ikegawa, S & Chan, D 2008, 'Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians', American Journal of Human Genetics, vol. 82, no. 3, pp. 744-747. https://doi.org/10.1016/j.ajhg.2007.12.017

TY - JOUR

T1 - Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

AU - Song, You Qiang

AU - Cheung, Kenneth M.C.

AU - Ho, Daniel W.H.

AU - Poon, Sandy C.S.

AU - Chiba, Kazuhiro

AU - Kawaguchi, Yoshiharu

AU - Hirose, Yuichiro

AU - Alini, Mauro

AU - Grad, Sibylle

AU - Yee, Anita F.Y.

AU - Leong, John C C.Y.

AU - Luk, Keith D.K.

AU - Yip, Shea Ping

AU - Karppinen, Jaro

AU - Cheah, Kathryn S.E.

AU - Sham, Pak

AU - Ikegawa, Shiro

AU - Chan, Danny

N1 - Funding Information: We thank Ms. Pei Yu for coordinating blood collection and assistance in MRI and questionnaire acquisition. This work was supported by grants from the University Grants Committee of Hong Kong (AoE/M-04/04) and grant-in-aid from Ministry of Education, Culture, Sports and Science of Japan (Contract grant number: 19209049).

PY - 2008/3/3

Y1 - 2008/3/3

N2 - Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.

AB - Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.

UR - https://www.scopus.com/pages/publications/41149171224

U2 - 10.1016/j.ajhg.2007.12.017

DO - 10.1016/j.ajhg.2007.12.017

M3 - Article

C2 - 18304494

AN - SCOPUS:41149171224

SN - 0002-9297

VL - 82

SP - 744

EP - 747

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -

Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

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