TY - JOUR
T1 - Association of Cancer and the Risk of Developing Atrial Fibrillation
T2 - A Systematic Review and Meta-Analysis
AU - Yuan, Ming
AU - Zhang, Zhiwei
AU - Tse, Gary
AU - Feng, Xiaojin
AU - Korantzopoulos, Panagiotis
AU - Letsas, Konstantinos P.
AU - Yan, Bryan P.
AU - Wu, William K.K.
AU - Zhang, Huilai
AU - Li, Guangping
AU - Liu, Tong
AU - Xia, Yunlong
N1 - Publisher Copyright:
© 2019 Ming Yuan et al.
PY - 2019
Y1 - 2019
N2 - Aims. Previous studies have demonstrated epidemiological evidence for an association between cancer and the development of new-onset atrial fibrillation (AF). However, these results have been conflicting. This systematic review and meta-analysis was conducted to examine the relationship between cancer and the risk of developing atrial fibrillation. Methods. PubMed and Web of Science were searched for publications examining the association between cancer and atrial fibrillation risk published until June 2017. Adjusted odds ratios (ORs) or hazard ratios (HRs) and 95% CI were extracted and pooled. Results. A total of five studies involving 5,889,234 subjects were included in this meta-analysis. Solid cancer patients are at higher risk developing atrial fibrillation compared to noncancer patients (OR 1.47, 95% CI 1.31 to 1.66, p<0.00001; I2 = 67%, p=0.02). The risk of atrial fibrillation was highest within 90 days of cancer diagnosis (OR 7.62, 95% CI 3.08 to 18.88, p<0.00001) and this risk diminished with time. Conclusions. The risk of AF was highest within 90 days of cancer diagnosis. We should take into account the increased risk of atrial fibrillation development and, after this, study the embolic risk and potential indication of oral anticoagulation.
AB - Aims. Previous studies have demonstrated epidemiological evidence for an association between cancer and the development of new-onset atrial fibrillation (AF). However, these results have been conflicting. This systematic review and meta-analysis was conducted to examine the relationship between cancer and the risk of developing atrial fibrillation. Methods. PubMed and Web of Science were searched for publications examining the association between cancer and atrial fibrillation risk published until June 2017. Adjusted odds ratios (ORs) or hazard ratios (HRs) and 95% CI were extracted and pooled. Results. A total of five studies involving 5,889,234 subjects were included in this meta-analysis. Solid cancer patients are at higher risk developing atrial fibrillation compared to noncancer patients (OR 1.47, 95% CI 1.31 to 1.66, p<0.00001; I2 = 67%, p=0.02). The risk of atrial fibrillation was highest within 90 days of cancer diagnosis (OR 7.62, 95% CI 3.08 to 18.88, p<0.00001) and this risk diminished with time. Conclusions. The risk of AF was highest within 90 days of cancer diagnosis. We should take into account the increased risk of atrial fibrillation development and, after this, study the embolic risk and potential indication of oral anticoagulation.
UR - http://www.scopus.com/inward/record.url?scp=85065234239&partnerID=8YFLogxK
U2 - 10.1155/2019/8985273
DO - 10.1155/2019/8985273
M3 - Review article
AN - SCOPUS:85065234239
SN - 2090-8016
VL - 2019
JO - Cardiology Research and Practice
JF - Cardiology Research and Practice
M1 - 8985273
ER -
