Association between immune checkpoint inhibitors and myocardial infarction in Asians: A population-based self-controlled case series

Jeffrey Shi Kai Chan, Pias Tang, Teddy Tai Loy Lee, Oscar Hou In Chou, Yan Hiu Athena Lee, Guoliang Li, Fung Ping Leung, Wing Tak Wong, Tong Liu, Gary Tse

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: While immune checkpoint inhibitors (ICIs) are associated with elevated cardiovascular risks, evidence of any association between ICIs and myocardial infarction (MI) was scarce, especially in Asians. Methods: Using prospectively collected population-based data, this self-controlled case series included patients prescribed an ICI between 1/1/2014 and 31/12/2020 in Hong Kong who had MI within January 1, 2013 to December 31, 2021. Incidence rate ratios (IRRs) for MI during and after ICI exposure were estimated, compared to the year before ICI initiation. Results: Of 3684 identified ICI users, 24 had MI during the study period. MI incidence increased significantly in the first 90 days of exposure (IRR 3.59 [95% confidence interval: 1.31–9.83], p = 0.013), but not days 91–180 (p = 0.148) or ≥181 (p = 0.591) of exposure, nor postexposure (p = 0.923). Sensitivity analyses excluding patients with MI-related death and incorporating extended exposure periods produced consistent results separately. Conclusions: ICIs were associated with increased MI incidence in Asian Chinese patients during the first 90 days of use, but not later.

Original languageEnglish
Pages (from-to)9541-9546
Number of pages6
JournalCancer Medicine
Volume12
Issue number8
DOIs
Publication statusPublished - Apr 2023

Keywords

  • cancer management
  • check point control
  • clinical cancer research
  • epidemiology

Fingerprint

Dive into the research topics of 'Association between immune checkpoint inhibitors and myocardial infarction in Asians: A population-based self-controlled case series'. Together they form a unique fingerprint.

Cite this