An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment

Lichun Ma; Debby D. Wang; Bin Zou; Hong Yan

doi:10.1109/TCBB.2016.2568184

An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment

Lichun Ma, Debby D. Wang, Bin Zou, Hong Yan

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We explore the drug resistance mechanism in non-small cell lung cancer treatment by characterizing the drug-binding site of a protein mutant based on local surface and energy features. These features are transformed to an eigen-binding site space and used for drug resistance level prediction and analysis.

Original language	English
Article number	7469333
Pages (from-to)	1187-1194
Number of pages	8
Journal	IEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume	14
Issue number	5
DOIs	https://doi.org/10.1109/TCBB.2016.2568184
Publication status	Published - 1 Sept 2017
Externally published	Yes

Keywords

Epidermal growth factor receptor
alpha shape modeling
binding free energy
binding site
gefitinib
non-small-cell lung carcinoma
tyrosine kinase inhibitor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TCBB.2016.2568184

Cite this

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title = "An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment",

abstract = "We explore the drug resistance mechanism in non-small cell lung cancer treatment by characterizing the drug-binding site of a protein mutant based on local surface and energy features. These features are transformed to an eigen-binding site space and used for drug resistance level prediction and analysis.",

keywords = "Epidermal growth factor receptor, alpha shape modeling, binding free energy, binding site, gefitinib, non-small-cell lung carcinoma, tyrosine kinase inhibitor",

author = "Lichun Ma and Wang, {Debby D.} and Bin Zou and Hong Yan",

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AU - Ma, Lichun

AU - Wang, Debby D.

AU - Zou, Bin

AU - Yan, Hong

PY - 2017/9/1

Y1 - 2017/9/1

N2 - We explore the drug resistance mechanism in non-small cell lung cancer treatment by characterizing the drug-binding site of a protein mutant based on local surface and energy features. These features are transformed to an eigen-binding site space and used for drug resistance level prediction and analysis.

AB - We explore the drug resistance mechanism in non-small cell lung cancer treatment by characterizing the drug-binding site of a protein mutant based on local surface and energy features. These features are transformed to an eigen-binding site space and used for drug resistance level prediction and analysis.

KW - Epidermal growth factor receptor

KW - alpha shape modeling

KW - binding free energy

KW - binding site

KW - gefitinib

KW - non-small-cell lung carcinoma

KW - tyrosine kinase inhibitor

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U2 - 10.1109/TCBB.2016.2568184

DO - 10.1109/TCBB.2016.2568184

M3 - Article

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AN - SCOPUS:85032445851

SN - 1545-5963

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SP - 1187

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JO - IEEE/ACM Transactions on Computational Biology and Bioinformatics

JF - IEEE/ACM Transactions on Computational Biology and Bioinformatics

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M1 - 7469333

ER -

An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment

Abstract

Keywords

UN SDGs

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