An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods

Leo W.Y. Yeung; Sachi Taniyasu; Kurunthachalam Kannan; Della Z.Y. Xu; Keerthi S. Guruge; Paul K.S. Lam; Nobuyoshi Yamashita

doi:10.1016/j.chroma.2009.04.070

An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods

Leo W.Y. Yeung
, Sachi Taniyasu
, Kurunthachalam Kannan
, Della Z.Y. Xu
, Keerthi S. Guruge
, Paul K.S. Lam
, Nobuyoshi Yamashita

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

A method for the analysis of perfluorinated compounds (perfluoroalkyl sulfonates: C4, C6, C8, C10; perfluoroalkyl sulfinates: C6, C8, C10; perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamidoacetate, perfluorocarboxylates: C4-C14; fluorotelomer carboxylate (7:3, 8:2) in whole blood using acetonitrile and OASIS WAX^® solid phase extraction (SPE) cartridge was developed. Separation of target compounds in two HPLC columns (ion exchange JJ50-2D and C18 Betasil columns) was examined. Matrix recoveries of the developed methods ranged from 70% to 120%. Separation of possible inferences such as taurodeoxycholic acid (TDC) was accomplished using an ion exchange JJ50-2D column, and this separation was validated using whole blood of different animals.

Original language	English
Pages (from-to)	4950-4956
Number of pages	7
Journal	Journal of Chromatography A
Volume	1216
Issue number	25
DOIs	https://doi.org/10.1016/j.chroma.2009.04.070
Publication status	Published - 19 Jun 2009
Externally published	Yes

Keywords

Acetonitrile
Formic acid
Perfluorooctanesulfonate
Solid phase extraction
Taurodeoxycholic acid
Whole blood

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10.1016/j.chroma.2009.04.070

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@article{a90d826024f14e1896759123af8ecf42,

title = "An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods",

abstract = "A method for the analysis of perfluorinated compounds (perfluoroalkyl sulfonates: C4, C6, C8, C10; perfluoroalkyl sulfinates: C6, C8, C10; perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamidoacetate, perfluorocarboxylates: C4-C14; fluorotelomer carboxylate (7:3, 8:2) in whole blood using acetonitrile and OASIS WAX{\textregistered} solid phase extraction (SPE) cartridge was developed. Separation of target compounds in two HPLC columns (ion exchange JJ50-2D and C18 Betasil columns) was examined. Matrix recoveries of the developed methods ranged from 70\% to 120\%. Separation of possible inferences such as taurodeoxycholic acid (TDC) was accomplished using an ion exchange JJ50-2D column, and this separation was validated using whole blood of different animals.",

keywords = "Acetonitrile, Formic acid, Perfluorooctanesulfonate, Solid phase extraction, Taurodeoxycholic acid, Whole blood",

author = "Yeung, \{Leo W.Y.\} and Sachi Taniyasu and Kurunthachalam Kannan and Xu, \{Della Z.Y.\} and Guruge, \{Keerthi S.\} and Lam, \{Paul K.S.\} and Nobuyoshi Yamashita",

note = "Funding Information: This work was undertaken during tenure of a City University Postgraduate Studentship and Research Activity Fund from City University of Hong Kong to LWYY. PKSL would like to acknowledge the support of a Strategic Research Grant (7002293) from City University of Hong Kong. ",

year = "2009",

month = jun,

day = "19",

doi = "10.1016/j.chroma.2009.04.070",

language = "English",

volume = "1216",

pages = "4950--4956",

number = "25",

}

TY - JOUR

T1 - An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods

AU - Yeung, Leo W.Y.

AU - Taniyasu, Sachi

AU - Kannan, Kurunthachalam

AU - Xu, Della Z.Y.

AU - Guruge, Keerthi S.

AU - Lam, Paul K.S.

AU - Yamashita, Nobuyoshi

N1 - Funding Information: This work was undertaken during tenure of a City University Postgraduate Studentship and Research Activity Fund from City University of Hong Kong to LWYY. PKSL would like to acknowledge the support of a Strategic Research Grant (7002293) from City University of Hong Kong.

PY - 2009/6/19

Y1 - 2009/6/19

N2 - A method for the analysis of perfluorinated compounds (perfluoroalkyl sulfonates: C4, C6, C8, C10; perfluoroalkyl sulfinates: C6, C8, C10; perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamidoacetate, perfluorocarboxylates: C4-C14; fluorotelomer carboxylate (7:3, 8:2) in whole blood using acetonitrile and OASIS WAX® solid phase extraction (SPE) cartridge was developed. Separation of target compounds in two HPLC columns (ion exchange JJ50-2D and C18 Betasil columns) was examined. Matrix recoveries of the developed methods ranged from 70% to 120%. Separation of possible inferences such as taurodeoxycholic acid (TDC) was accomplished using an ion exchange JJ50-2D column, and this separation was validated using whole blood of different animals.

AB - A method for the analysis of perfluorinated compounds (perfluoroalkyl sulfonates: C4, C6, C8, C10; perfluoroalkyl sulfinates: C6, C8, C10; perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamidoacetate, perfluorocarboxylates: C4-C14; fluorotelomer carboxylate (7:3, 8:2) in whole blood using acetonitrile and OASIS WAX® solid phase extraction (SPE) cartridge was developed. Separation of target compounds in two HPLC columns (ion exchange JJ50-2D and C18 Betasil columns) was examined. Matrix recoveries of the developed methods ranged from 70% to 120%. Separation of possible inferences such as taurodeoxycholic acid (TDC) was accomplished using an ion exchange JJ50-2D column, and this separation was validated using whole blood of different animals.

KW - Acetonitrile

KW - Formic acid

KW - Perfluorooctanesulfonate

KW - Solid phase extraction

KW - Taurodeoxycholic acid

KW - Whole blood

UR - https://www.scopus.com/pages/publications/65649149109

U2 - 10.1016/j.chroma.2009.04.070

DO - 10.1016/j.chroma.2009.04.070

M3 - Article

C2 - 19439311

AN - SCOPUS:65649149109

SN - 0021-9673

VL - 1216

SP - 4950

EP - 4956

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - 25

ER -

An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods

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Keywords

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