Personal profile
Biography
After post-doctoral training, Dr Chan was promoted to Research Assistant Professor at the Department of Pathology, The University of Hong Kong. He subsequently joined the Prenatal Diagnostic Laboratory (PDL), Department of Obstetrics and Gynaecology, Tsan Yuk Hospital and Queen Mary Hospital as a Scientific Officer (Medical). He was appointed as Quality Manager and then Laboratory Director, overseeing the PDL providing prenatal diagnostic and screening services. Before joining HKMU, he was promoted to Senior Scientific Officer in Hong Kong Genome Institute to oversee the laboratory setup and operation for the Hong Kong Genome Project (HKGP), which is the first popluation scale human genome project in Hong Kong.
He has authored and co-authored in over 100 papers and reviews in peer reviewed and international journals, including Nature Genetics, Nature Communication, Cancer Research, PLOS Genetics, PLOS One, NPJ Genomic Medicine, Prenatal Diagnosis, American Journal of Medical Genetics (Part A and C). Scopus Author Identifier: 7406034195 (Holding h-index of 33 and total of citation over 3000 times, as of June 2023).
He currently serves in a number of peer reviewed journals:
- Guest Editor for a special issue “Fetal Medicine: From Basic Science to Prenatal Diagnosis and Therapy” in Diagnostics
- Review Editor for Frontiers in Pediatrics (Genetics of Common and Rare Diseases)
- Associate Editor and Review Editor for Frontiers in Genetics (Human and Medical Genomics)
- Associate Editor for BMC Medical Genomics
- Editorial board for Scient Open Access, Women's Health & Gynecology
- Academic Editor for an international peer-reviewed journal, PLoS One
Research interests
Diagnostic application of molecular profiling, genotyping, and genetic variation analysis in human diseases; study of underlying mechanisms for the development and manifestation of human diseases and cancers
Memberships
- Registered Medical Laboratory Technologist (Part I, Reg. No. MT102726), HK MLT Board
- Fellow Member, Hong Kong Society of Cytogenomics
- Ordinary Member, Hong Kong Society of Medical Genetics
Appointments
- Honorary Assistant Professor (Department of Pathology, HKU)
- Honorary Research Fellow (Department of Pathology, HKU-ShenZhen Hospital)
Education/Academic qualification
Doctor, The University of Hong Kong
External positions
Honorary Research Fellow
27 Jul 2023 → 26 Jul 2025
Medical Laboratory Assessor, Hong Kong Laboratory Accreditation Scheme (HOKLAS)
Board Member, Hong Kong Medical Laboratory Technologist (MLT) Board
Chairman of the Board Registration Committee (BRC), Hong Kong Medical Laboratory Technologist (MLT) Board
Member of the Board Examination Committee (BEC), Hong Kong Medical Laboratory Technologist (MLT) Board
Member of the Registration Committee, Supplementary Medical Professional (SMP) Council
Honorary Assistant Professor, Department of Pathology, The University of Hong Kong
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 17 Partnerships for the Goals
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Collaborations and top research areas from the last five years
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EXPRESSION OF CONCERN: Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer (Oncology Reports (2008) 19 (1339-1345) DOI: 10.3892/or.19.5.1339)
Leung, R. C. Y., Liu, S. S., Chan, K. Y. K., Tam, K. F., Chan, K. L., Wong, L. C. & Ngan, H. Y. S., Jan 2026, In: Oncology Reports. 55, 1, 23.Research output: Contribution to journal › Comment/debate
Open Access -
Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer
Tsoi, H., Leung, G. M. H., Man, E. P. S., You, C. P., Cheung, K. H. L., Chan, K. Y. K., Gong, C., Huen, M. S. Y. & Khoo, U. S., Dec 2025, In: Journal of Translational Medicine. 23, 1, 860.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Prenatal Phenotype in a Neonate with Prader–Willi Syndrome and Literature Review
Luo, L., Tang, M. H. Y., Lin, S., Kan, A. S. Y., Cheung, C. K. Y., Dai, X., Zeng, T., Li, Y., Nong, L., Huang, H., Chen, C., Xu, Y. & Chan, K. Y. K., Jul 2025, In: Diagnostics. 15, 13, 1666.Research output: Contribution to journal › Article › peer-review
Open Access -
Fetal Hyperthyroidism with Maternal Hypothyroidism: Two Cases of Intrauterine Therapy
Hong, L., Tang, M. H. Y., Cheung, K. W., Luo, L., Cheung, C. K. Y., Dai, X., Li, Y., Xiong, C., Liang, W., Xiang, W., Wang, L., Chan, K. Y. K. & Lin, S., Jan 2024, In: Diagnostics. 14, 1, 102.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Global trajectory and future prospects of metronomic chemotherapy research: A scientometric analysis (2000-2022)
Khan, S. A., Chan, K. Y. K. & Lee, T. K. W., 1 Nov 2023, In: Cancer Letters. 576, 216401.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
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Study of a fusion gene candidate resulting from chromatin architecture modulation in ER positive breast cancer
CHAN, K. Y. K. (PI), Ui-Soon, K. (CoI) & SUNG Wing-kin (CoI)
1/12/25 → 30/11/26
Project: Research
Activities
- 6 Editorial work
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Diagnostics (Journal)
CHAN, K. Y. K. (Member of Advisory Board)
2023 → …Activity: Publication peer-review and editorial work › Editorial work
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Frontiers in Pediatrics (Journal)
CHAN, K. Y. K. (Member of Advisory Board)
2021 → …Activity: Publication peer-review and editorial work › Editorial work
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Frontiers in Genetics (Journal)
CHAN, K. Y. K. (Member of Advisory Board)
2020 → …Activity: Publication peer-review and editorial work › Editorial work
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BMC Medical Genomics (Journal)
CHAN, K. Y. K. (Member of Advisory Board)
2019 → …Activity: Publication peer-review and editorial work › Editorial work
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Scient Open Access, Women's Health & Gynecology (Journal)
CHAN, K. Y. K. (Member of Advisory Board)
2016 → …Activity: Publication peer-review and editorial work › Editorial work